6FFC

Structure of an inhibitor-bound ABC transporter

Summary for 6FFC

Entry DOI	10.2210/pdb6ffc/pdb
EMDB information	4256
Descriptor	ATP-binding cassette sub-family G member 2, ~{tert}-butyl 3-[(2~{S},5~{S},8~{S})-14-cyclopentyloxy-2-(2-methylpropyl)-4,7-bis(oxidanylidene)-3,6,17-triazatetracyclo[8.7.0.0^{3,8}.0^{11,16}]heptadeca-1(10),11,13,15-tetraen-5-yl]propanoate (2 entities in total)
Functional Keywords	abc transporter, transport protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	147838.81
Authors	Jackson, S.M.,Manolaridis, I.,Kowal, J.,Zechner, M.,Taylor, N.M.I.,Bause, M.,Bauer, S.,Bartholomaeus, R.,Stahlberg, H.,Bernhardt, G.,Koenig, B.,Buschauer, A.,Altmann, K.H.,Locher, K.P. (deposition date: 2018-01-06, release date: 2018-04-11, Last modification date: 2019-12-11)
Primary citation	Jackson, S.M.,Manolaridis, I.,Kowal, J.,Zechner, M.,Taylor, N.M.I.,Bause, M.,Bauer, S.,Bartholomaeus, R.,Bernhardt, G.,Koenig, B.,Buschauer, A.,Stahlberg, H.,Altmann, K.H.,Locher, K.P. Structural basis of small-molecule inhibition of human multidrug transporter ABCG2. Nat. Struct. Mol. Biol., 25:333-340, 2018 Cited by PubMed: 29610494 DOI: 10.1038/s41594-018-0049-1 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.56 Å)

Structure validation