6HIJ

Cryo-EM structure of the human ABCG2-MZ29-Fab complex with cholesterol and PE lipids docked

Summary for 6HIJ

• Entry DOI: 10.2210/pdb6hij/pdb
• Related: 6FFC
• EMDB information: 4256 4256
• Descriptor: ATP-binding cassette sub-family G member 2, 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, CHOLESTEROL, ... (4 entities in total)
• Functional Keywords: abc transporter, transport protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 155678.16

Authors

Jackson, S.M.,Manolaridis, I.,Kowal, J.,Zechner, M.,Taylor, N.M.I.,Bause, M.,Bauer, S.,Bartholomaeus, R.,Stahlberg, H.,Bernhardt, G.,Koenig, B.,Buschauer, A.,Altmann, K.H.,Locher, K.P. (deposition date: 2018-08-30, release date: 2018-09-19, Last modification date: 2019-12-11)

• Primary citation: Jackson, S.M.,Manolaridis, I.,Kowal, J.,Zechner, M.,Taylor, N.M.I.,Bause, M.,Bauer, S.,Bartholomaeus, R.,Bernhardt, G.,Koenig, B.,Buschauer, A.,Stahlberg, H.,Altmann, K.H.,Locher, K.P.; Structural basis of small-molecule inhibition of human multidrug transporter ABCG2.; Nat.Struct.Mol.Biol., 25:333-340, 2018; PubMed: 29610494; DOI: 10.1038/s41594-018-0049-1

Experimental method

ELECTRON MICROSCOPY (3.56 Å)