6HIJ
Cryo-EM structure of the human ABCG2-MZ29-Fab complex with cholesterol and PE lipids docked
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006869 | biological_process | lipid transport |
| A | 0008559 | molecular_function | ABC-type xenobiotic transporter activity |
| A | 0015143 | molecular_function | urate transmembrane transporter activity |
| A | 0015225 | molecular_function | biotin transmembrane transporter activity |
| A | 0015562 | molecular_function | efflux transmembrane transporter activity |
| A | 0015711 | biological_process | organic anion transport |
| A | 0015747 | biological_process | urate transport |
| A | 0015878 | biological_process | biotin transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0030148 | biological_process | sphingolipid biosynthetic process |
| A | 0031526 | cellular_component | brush border membrane |
| A | 0031966 | cellular_component | mitochondrial membrane |
| A | 0032217 | molecular_function | riboflavin transmembrane transporter activity |
| A | 0032218 | biological_process | riboflavin transport |
| A | 0042626 | molecular_function | ATPase-coupled transmembrane transporter activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| A | 0045121 | cellular_component | membrane raft |
| A | 0046415 | biological_process | urate metabolic process |
| A | 0046624 | molecular_function | sphingolipid transporter activity |
| A | 0046983 | molecular_function | protein dimerization activity |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0070633 | biological_process | transepithelial transport |
| A | 0097744 | biological_process | renal urate salt excretion |
| A | 0098591 | cellular_component | external side of apical plasma membrane |
| A | 0140115 | biological_process | export across plasma membrane |
| A | 0140359 | molecular_function | ABC-type transporter activity |
| A | 0150104 | biological_process | transport across blood-brain barrier |
| A | 1990748 | biological_process | cellular detoxification |
| A | 1990961 | biological_process | xenobiotic detoxification by transmembrane export across the plasma membrane |
| A | 1990962 | biological_process | xenobiotic transport across blood-brain barrier |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006869 | biological_process | lipid transport |
| B | 0008559 | molecular_function | ABC-type xenobiotic transporter activity |
| B | 0015143 | molecular_function | urate transmembrane transporter activity |
| B | 0015225 | molecular_function | biotin transmembrane transporter activity |
| B | 0015562 | molecular_function | efflux transmembrane transporter activity |
| B | 0015711 | biological_process | organic anion transport |
| B | 0015747 | biological_process | urate transport |
| B | 0015878 | biological_process | biotin transport |
| B | 0016020 | cellular_component | membrane |
| B | 0016324 | cellular_component | apical plasma membrane |
| B | 0016887 | molecular_function | ATP hydrolysis activity |
| B | 0022857 | molecular_function | transmembrane transporter activity |
| B | 0030148 | biological_process | sphingolipid biosynthetic process |
| B | 0031526 | cellular_component | brush border membrane |
| B | 0031966 | cellular_component | mitochondrial membrane |
| B | 0032217 | molecular_function | riboflavin transmembrane transporter activity |
| B | 0032218 | biological_process | riboflavin transport |
| B | 0042626 | molecular_function | ATPase-coupled transmembrane transporter activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| B | 0045121 | cellular_component | membrane raft |
| B | 0046415 | biological_process | urate metabolic process |
| B | 0046624 | molecular_function | sphingolipid transporter activity |
| B | 0046983 | molecular_function | protein dimerization activity |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0070633 | biological_process | transepithelial transport |
| B | 0097744 | biological_process | renal urate salt excretion |
| B | 0098591 | cellular_component | external side of apical plasma membrane |
| B | 0140115 | biological_process | export across plasma membrane |
| B | 0140359 | molecular_function | ABC-type transporter activity |
| B | 0150104 | biological_process | transport across blood-brain barrier |
| B | 1990748 | biological_process | cellular detoxification |
| B | 1990961 | biological_process | xenobiotic detoxification by transmembrane export across the plasma membrane |
| B | 1990962 | biological_process | xenobiotic transport across blood-brain barrier |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue PEE A 701 |
| Chain | Residue |
| A | GLN393 |
| A | ILE396 |
| A | VAL401 |
| A | VAL404 |
| B | PHE547 |
| B | CLR702 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue CLR A 702 |
| Chain | Residue |
| A | PHE571 |
| A | TYR576 |
| A | CYS635 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue CLR A 703 |
| Chain | Residue |
| A | PHE547 |
| A | MET548 |
| A | PHE551 |
| A | LEU568 |
| A | PHE640 |
| A | LYS647 |
| B | PEE709 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue CLR A 704 |
| Chain | Residue |
| A | SER467 |
| A | THR642 |
| A | TYR645 |
| A | PEE709 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue CLR A 705 |
| Chain | Residue |
| A | MET510 |
| A | MET514 |
| A | TRP627 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue CLR A 706 |
| Chain | Residue |
| A | ARG378 |
| A | SER381 |
| A | LEU475 |
| A | MET483 |
| A | LEU484 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | binding site for residue PEE A 707 |
| Chain | Residue |
| A | PEE708 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue PEE A 708 |
| Chain | Residue |
| A | TRP624 |
| A | TRP627 |
| A | PEE707 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue PEE A 709 |
| Chain | Residue |
| A | ARG465 |
| A | CLR704 |
| site_id | AD1 |
| Number of Residues | 15 |
| Details | binding site for residue BWQ A 710 |
| Chain | Residue |
| A | ALA397 |
| A | VAL401 |
| A | LEU405 |
| A | PHE431 |
| A | PHE432 |
| A | THR435 |
| A | ASN436 |
| A | PHE439 |
| B | LEU539 |
| B | THR542 |
| B | ILE543 |
| B | VAL546 |
| B | MET549 |
| B | LEU555 |
| B | BWQ710 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue CLR B 701 |
| Chain | Residue |
| B | PHE571 |
| B | TYR576 |
| B | CYS635 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue CLR B 702 |
| Chain | Residue |
| A | PEE701 |
| B | PHE547 |
| B | MET548 |
| B | PHE551 |
| B | LEU568 |
| B | PHE640 |
| B | LYS647 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue CLR B 703 |
| Chain | Residue |
| B | SER467 |
| B | TYR645 |
| B | PEE708 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue CLR B 704 |
| Chain | Residue |
| B | MET510 |
| B | MET514 |
| B | TRP627 |
| site_id | AD6 |
| Number of Residues | 1 |
| Details | binding site for residue PEE B 707 |
| Chain | Residue |
| B | TRP624 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue PEE B 708 |
| Chain | Residue |
| B | PHE373 |
| B | ARG465 |
| B | CLR703 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue PEE B 709 |
| Chain | Residue |
| A | PHE547 |
| A | CLR703 |
| B | GLN393 |
| B | ILE396 |
| site_id | AD9 |
| Number of Residues | 16 |
| Details | binding site for residue BWQ B 710 |
| Chain | Residue |
| A | LEU539 |
| A | THR542 |
| A | ILE543 |
| A | VAL546 |
| A | MET549 |
| A | LEU555 |
| A | BWQ710 |
| B | ALA397 |
| B | VAL401 |
| B | LEU405 |
| B | PHE431 |
| B | PHE432 |
| B | THR435 |
| B | ASN436 |
| B | PHE439 |
| B | SER440 |
| site_id | AE1 |
| Number of Residues | 9 |
| Details | binding site for Di-peptide CLR B 705 and LEU B 484 |
| Chain | Residue |
| B | SER381 |
| B | LEU475 |
| B | PRO480 |
| B | ARG482 |
| B | MET483 |
| B | PRO485 |
| B | SER486 |
| B | ILE487 |
| B | ILE488 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 240 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 182 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 68 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 524 |
| Details | Domain: {"description":"ABC transmembrane type-2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"30405239","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6HBU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6HZM","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"30405239","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6HBU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6HZM","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Site: {"description":"Not glycosylated","evidences":[{"source":"PubMed","id":"15807535","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"15807535","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28554189","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5NJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5NJG","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
