7OJI
ABCG2 topotecan turnover-2 state
Summary for 7OJI
Entry DOI | 10.2210/pdb7oji/pdb |
EMDB information | 12939 12951 12952 |
Descriptor | Broad substrate specificity ATP-binding cassette transporter ABCG2, (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, CHOLESTEROL, ... (5 entities in total) |
Functional Keywords | abc transporter plasma membrane atp multidrug resistance, transport protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 151281.97 |
Authors | Yu, Q.,Ni, D.,Kowal, J.,Manolaridis, I.,Jackson, S.M.,Stahlberg, H.,Locher, K.P. (deposition date: 2021-05-16, release date: 2021-07-21, Last modification date: 2021-07-28) |
Primary citation | Yu, Q.,Ni, D.,Kowal, J.,Manolaridis, I.,Jackson, S.M.,Stahlberg, H.,Locher, K.P. Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism. Nat Commun, 12:4376-4376, 2021 Cited by PubMed: 34282134DOI: 10.1038/s41467-021-24651-2 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.4 Å) |
Structure validation
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