7OJI
ABCG2 topotecan turnover-2 state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Broad substrate specificity ATP-binding cassette transporter ABCG2 | polymer | 665 | 73526.9 | 2 | UniProt (Q9UNQ0) Pfam (PF00005) Pfam (PF19055) Pfam (PF01061) | Homo sapiens (human) | ATP-binding cassette sub-family G member 2,Breast cancer resistance protein,CDw338,Mitoxantrone resistance-associated protein,Placenta-specific ATP-binding cassette transporter,Urate exporter |
| 2 | C (A) | (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE | non-polymer | 421.4 | 1 | Chemie (TTC) | |||
| 3 | D, F, H, I (A, B) | CHOLESTEROL | non-polymer | 386.7 | 4 | Chemie (CLR) | |||
| 4 | E, J (A, B) | DIUNDECYL PHOSPHATIDYL CHOLINE | non-polymer | 622.8 | 2 | Chemie (PLC) | |||
| 5 | G, K (A, B) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) |
Sequence modifications
A, B: 2 - 655 (UniProt: Q9UNQ0)
| PDB | External Database | Details |
|---|---|---|
| Met -9 | - | initiating methionine |
| Asp -8 | - | expression tag |
| Tyr -7 | - | expression tag |
| Lys -6 | - | expression tag |
| Asp -5 | - | expression tag |
| Asp -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Asp -2 | - | expression tag |
| Lys -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Ser 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 147053.9 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 4228.1 | |
| All* | Total formula weight | 151282.0 |
