6HZM

Cryo-EM structure of the ABCG2 E211Q mutant bound to ATP and Magnesium (alternative placement of Magnesium into the cryo-EM density)

Summary for 6HZM

Entry DOI	10.2210/pdb6hzm/pdb
Related	6HBU
EMDB information	0190
Descriptor	ATP-binding cassette sub-family G member 2, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	multidrug transporter, membrane protein, cancer
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	145832.71
Authors	Manolaridis, I.,Jackson, S.M.,Taylor, N.M.I.,Kowal, J.,Stahlberg, H.,Locher, K.P. (deposition date: 2018-10-23, release date: 2018-11-14, Last modification date: 2019-12-18)
Primary citation	Manolaridis, I.,Jackson, S.M.,Taylor, N.M.I.,Kowal, J.,Stahlberg, H.,Locher, K.P. Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states. Nature, 563:426-430, 2018 Cited by PubMed: 30405239 DOI: 10.1038/s41586-018-0680-3 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.09 Å)

Structure validation