7OJH

ABCG2 topotecan turnover-1 state

Summary for 7OJH

Entry DOI	10.2210/pdb7ojh/pdb
Related	7OJ8
EMDB information	12939 12951
Descriptor	Broad substrate specificity ATP-binding cassette transporter ABCG2, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, ... (4 entities in total)
Functional Keywords	abc transporter plasma membrane atp multidrug resistance, transport protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	149262.99
Authors	Yu, Q.,Ni, D.,Kowal, J.,Manolaridis, I.,Jackson, S.M.,Stahlberg, H.,Locher, K.P. (deposition date: 2021-05-15, release date: 2021-07-21, Last modification date: 2021-07-28)
Primary citation	Yu, Q.,Ni, D.,Kowal, J.,Manolaridis, I.,Jackson, S.M.,Stahlberg, H.,Locher, K.P. Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism. Nat Commun, 12:4376-4376, 2021 Cited by PubMed: 34282134 DOI: 10.1038/s41467-021-24651-2 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.1 Å)

Structure validation