1WAX

Protein tyrosine phosphatase 1B with active site inhibitor

Summary for 1WAX

Entry DOI	10.2210/pdb1wax/pdb
Related	1A5Y 1AAX 1BZC 1BZH 1BZJ 1C83 1C84 1C85 1C86 1C87 1C88 1ECV 1EEN 1EEO 1G1F 1G1G 1G1H 1G7F 1G7G 1GFY 1I57 1JF7 1KAK 1KAV 1L8G 1LQF 1NL9 1NNY 1NO6 1NWE 1NWL 1NZ7 1OEM 1OEO 1OES 1OET 1OEU 1OEV 1ONY 1ONZ 1PA1 1PH0 1PTT 1PTU 1PTV 1PTY 1PXH 1PYN 1Q1M 1Q6J 1Q6M 1Q6N 1Q6P 1Q6S 1Q6T 1QXK 1SUG 1T48 1T49 1T4J 1XBO 2HNP 2HNQ
Descriptor	PROTEIN-TYROSINE PHOSPHATASE, MAGNESIUM ION, [[4-(AMINOMETHYL)PHENYL]AMINO]OXO-ACETIC ACID,, ... (4 entities in total)
Functional Keywords	acetylation, hydrolase, phosphorylation, protein tyrosine phosphatase, inhibitors
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031
Total number of polymer chains	1
Total formula weight	37584.13
Authors	Hartshorn, M.J.,Murray, C.W.,Cleasby, A.,Frederickson, M.,Tickle, I.J.,Jhoti, H. (deposition date: 2004-10-28, release date: 2005-01-27, Last modification date: 2023-12-13)
Primary citation	Hartshorn, M.J.,Murray, C.W.,Cleasby, A.,Frederickson, M.,Tickle, I.J.,Jhoti, H. Fragment-Based Lead Discovery Using X-Ray Crystallography J.Med.Chem., 48:403-, 2005 Cited by PubMed: 15658854 DOI: 10.1021/JM0495778 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation