1Q6M

THE STRUCTURE OF PHOSPHOTYROSINE PHOSPHATASE 1B IN COMPLEX WITH COMPOUND 3

Summary for 1Q6M

Entry DOI	10.2210/pdb1q6m/pdb
Related	1Q6J 1Q6N 1Q6P 1Q6S 1Q6T
Descriptor	Protein-tyrosine phosphatase, non-receptor type 1, {[2-(1H-1,2,3-BENZOTRIAZOL-1-YL)-2-(3,4-DIFLUOROPHENYL)PROPANE-1,3-DIYL]BIS[4,1-PHENYLENE(DIFLUOROMETHYLENE)]}BIS(PHOSPHONIC ACID) (3 entities in total)
Functional Keywords	phosphatase, secondary binding site, selectivity, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031
Total number of polymer chains	1
Total formula weight	36923.62
Authors	Scapin, G.,Patel, S.B.,Becker, J.W.,Wang, Q.,Desponts, C.,Waddleton, D.,Skorey, K.,Cromlish, W.,Bayly, C.,Therien, M.,Gauthier, J.Y.,Li, C.S.,Lau, C.K.,Ramachandran, C.,Kennedy, B.P.,Asante-Appiah, E. (deposition date: 2003-08-13, release date: 2003-09-30, Last modification date: 2023-08-16)
Primary citation	Scapin, G.,Patel, S.B.,Becker, J.W.,Wang, Q.,Desponts, C.,Waddleton, D.,Skorey, K.,Cromlish, W.,Bayly, C.,Therien, M.,Gauthier, J.Y.,Li, C.S.,Lau, C.K.,Ramachandran, C.,Kennedy, B.P.,Asante-Appiah, E. The Structural Basis for the Selectivity of Benzotriazole Inhibitors of Ptp1B Biochemistry, 42:11451-11459, 2003 Cited by PubMed: 14516196 DOI: 10.1021/bi035098j PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation