1C83
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 6-(OXALYL-AMINO)-1H-INDOLE-5-CARBOXYLIC ACID
Summary for 1C83
Entry DOI | 10.2210/pdb1c83/pdb |
Related | 1C84 1C85 1C86 1C87 1C88 1ECV |
Descriptor | PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B), 6-(OXALYL-AMINO)-1H-INDOLE-5-CARBOXYLIC ACID (3 entities in total) |
Functional Keywords | hydrolase, phosphorylation, ligand, inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031 |
Total number of polymer chains | 1 |
Total formula weight | 34968.76 |
Authors | Andersen, H.S.,Iversen, L.F.,Branner, S.,Rasmussen, H.B.,Moller, N.P. (deposition date: 2000-04-14, release date: 2000-05-03, Last modification date: 2023-12-27) |
Primary citation | Andersen, H.S.,Iversen, L.F.,Jeppesen, C.B.,Branner, S.,Norris, K.,Rasmussen, H.B.,Moller, K.B.,Moller, N.P. 2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases. J.Biol.Chem., 275:7101-7108, 2000 Cited by PubMed: 10702277DOI: 10.1074/jbc.275.10.7101 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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