1ECV

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 5-IODO-2-(OXALYL-AMINO)-BENZOIC ACID

Summary for 1ECV

• Entry DOI: 10.2210/pdb1ecv/pdb
• Related: 1C83 1C84 1C85 1C86 1C87 1C88
• Descriptor: PROTEIN-TYROSINE PHOSPHATASE 1B, ACETATE ION, 5-IODO-2-(OXALYL-AMINO)-BENZOIC ACID, ... (4 entities in total)
• Functional Keywords: hydrolase, phosphorylation, ligand, inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031
• Total number of polymer chains: 1
• Total formula weight: 35232.75

Authors

Andersen, H.S.,Iversen, L.F.,Branner, S.,Rasmussen, H.B.,Moller, N.P.H. (deposition date: 2000-01-26, release date: 2000-03-15, Last modification date: 2024-02-07)

• Primary citation: Andersen, H.S.,Iversen, L.F.,Jeppesen, C.B.,Branner, S.,Norris, K.,Rasmussen, H.B.,Moller, K.B.,Moller, N.P.; 2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases.; J.Biol.Chem., 275:7101-7108, 2000; PubMed: 10702277; DOI: 10.1074/jbc.275.10.7101

Experimental method

X-RAY DIFFRACTION (1.95 Å)