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1C83

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 6-(OXALYL-AMINO)-1H-INDOLE-5-CARBOXYLIC ACID

Summary for 1C83
Entry DOI10.2210/pdb1c83/pdb
Related1C84 1C85 1C86 1C87 1C88 1ECV
DescriptorPROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B), 6-(OXALYL-AMINO)-1H-INDOLE-5-CARBOXYLIC ACID (3 entities in total)
Functional Keywordshydrolase, phosphorylation, ligand, inhibitor
Biological sourceHomo sapiens (human)
Cellular locationEndoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031
Total number of polymer chains1
Total formula weight34968.76
Authors
Andersen, H.S.,Iversen, L.F.,Branner, S.,Rasmussen, H.B.,Moller, N.P. (deposition date: 2000-04-14, release date: 2000-05-03, Last modification date: 2023-12-27)
Primary citationAndersen, H.S.,Iversen, L.F.,Jeppesen, C.B.,Branner, S.,Norris, K.,Rasmussen, H.B.,Moller, K.B.,Moller, N.P.
2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases.
J.Biol.Chem., 275:7101-7108, 2000
Cited by
PubMed: 10702277
DOI: 10.1074/jbc.275.10.7101
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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