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1I57

CRYSTAL STRUCTURE OF APO HUMAN PTP1B (C215S) MUTANT

Summary for 1I57
Entry DOI10.2210/pdb1i57/pdb
DescriptorPHOSPHO-TYROSINE PHOSPHATASE 1B, MAGNESIUM ION, CHLORIDE ION, ... (4 entities in total)
Functional Keywordssubstrate-trapping mutant, conformational change, wpd loop, phosphate-binding loop, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationEndoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031
Total number of polymer chains1
Total formula weight36423.68
Authors
Scapin, G.,Patel, S.,Patel, V.,Kennedy, B.,Asante-Appiah, E. (deposition date: 2001-02-26, release date: 2001-08-08, Last modification date: 2023-08-09)
Primary citationScapin, G.,Patel, S.,Patel, V.,Kennedy, B.,Asante-Appiah, E.
The structure of apo protein-tyrosine phosphatase 1B C215S mutant: more than just an S --> O change.
Protein Sci., 10:1596-1605, 2001
Cited by
PubMed: 11468356
DOI: 10.1110/ps.11001
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

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