1I57

CRYSTAL STRUCTURE OF APO HUMAN PTP1B (C215S) MUTANT

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	PHOSPHO-TYROSINE PHOSPHATASE 1B	polymer	310	36222.1	1	UniProt (P18031) Pfam (PF00102) In PDB	Homo sapiens (human)	PTP-1B, PROTEIN-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1, PROTEIN-TYROSINE PHOSPHATASE 1B
2	A	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
3	A	CHLORIDE ION	non-polymer		35.5	5	Chemie (CL)
4		water	water		18.0	250	Chemie (HOH)

Sequence modifications

A: 1 - 298 (UniProt: P18031)

PDB	External Database	Details
Met -11	-	SEE REMARK 999
Asp -10	-	SEE REMARK 999
Tyr -9	-	SEE REMARK 999
Lys -8	-	SEE REMARK 999
Asp -7	-	SEE REMARK 999
Asp -6	-	SEE REMARK 999
Asp -5	-	SEE REMARK 999
Asp -4	-	SEE REMARK 999
Lys -3	-	SEE REMARK 999
Leu -2	-	SEE REMARK 999
Glu -1	-	SEE REMARK 999
Phe 0	-	SEE REMARK 999
Ser 215	Cys 215	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	36222.1
Non-Polymers*	Number of molecules	6
	Total formula weight	201.6
All*	Total formula weight	36423.7

*Water molecules are not included.