1PXH

Crystal structure of protein tyrosine phosphatase 1B with potent and selective bidentate inhibitor compound 2

Replaces:  1N6W

Summary for 1PXH

• Entry DOI: 10.2210/pdb1pxh/pdb
• Related: 1N6W
• Descriptor: Protein-tyrosine phosphatase, non-receptor type 1, MAGNESIUM ION, N-{1-[5-(1-CARBAMOYL-2-MERCAPTO-ETHYLCARBAMOYL)-PENTYLCARBAMOYL]-2-[4-(DIFLUORO-PHOSPHONO-METHYL)-PHENYL]-ETHYL}-3-{2-[4-(DIFLUORO-PHOSPHONO-METHYL)-PHENYL]-ACETYLAMINO}-SUCCINAMIC ACID, ... (5 entities in total)
• Functional Keywords: protein tyrosine phosphatase, ptp1b, phosphatase inhibitor, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031
• Total number of polymer chains: 1
• Total formula weight: 38408.05

Authors

Sun, J.P.,Fedorov, A.,Lee, S.Y.,Guo, X.L.,Shen, K.,Lawrence, D.S.,Almo, S.C.,Zhang, Z.Y. (deposition date: 2003-07-04, release date: 2003-08-12, Last modification date: 2023-08-16)

• Primary citation: Sun, J.P.,Fedorov, A.A.,Lee, S.Y.,Guo, X.L.,Shen, K.,Lawrence, D.S.,Almo, S.C.,Zhang, Z.Y.; Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor.; J.Biol.Chem., 278:12406-12414, 2003; PubMed: 12547827; DOI: 10.1074/jbc.M212491200

Experimental method

X-RAY DIFFRACTION (2.15 Å)