1PXH
Crystal structure of protein tyrosine phosphatase 1B with potent and selective bidentate inhibitor compound 2
Replaces: 1N6WSummary for 1PXH
Entry DOI | 10.2210/pdb1pxh/pdb |
Related | 1N6W |
Descriptor | Protein-tyrosine phosphatase, non-receptor type 1, MAGNESIUM ION, N-{1-[5-(1-CARBAMOYL-2-MERCAPTO-ETHYLCARBAMOYL)-PENTYLCARBAMOYL]-2-[4-(DIFLUORO-PHOSPHONO-METHYL)-PHENYL]-ETHYL}-3-{2-[4-(DIFLUORO-PHOSPHONO-METHYL)-PHENYL]-ACETYLAMINO}-SUCCINAMIC ACID, ... (5 entities in total) |
Functional Keywords | protein tyrosine phosphatase, ptp1b, phosphatase inhibitor, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031 |
Total number of polymer chains | 1 |
Total formula weight | 38408.05 |
Authors | Sun, J.P.,Fedorov, A.,Lee, S.Y.,Guo, X.L.,Shen, K.,Lawrence, D.S.,Almo, S.C.,Zhang, Z.Y. (deposition date: 2003-07-04, release date: 2003-08-12, Last modification date: 2023-08-16) |
Primary citation | Sun, J.P.,Fedorov, A.A.,Lee, S.Y.,Guo, X.L.,Shen, K.,Lawrence, D.S.,Almo, S.C.,Zhang, Z.Y. Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor. J.Biol.Chem., 278:12406-12414, 2003 Cited by PubMed: 12547827DOI: 10.1074/jbc.M212491200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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