1BZJ

Human ptp1b complexed with tpicooh

Summary for 1BZJ

Entry DOI	10.2210/pdb1bzj/pdb
Descriptor	PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE), 6-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBOXYLIC ACID (3 entities in total)
Functional Keywords	phosphorylation, inhibitor complex, protein tyrosine phosphatase, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031
Total number of polymer chains	1
Total formula weight	34891.54
Authors	Groves, M.R.,Yao, Z.-J.,Barford Jr., D.T.B. (deposition date: 1998-10-29, release date: 1999-02-16, Last modification date: 2023-08-09)
Primary citation	Groves, M.R.,Yao, Z.-J.,Roller, P.P.,Burke Jr., T.R.,Barford, D. Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics. Biochemistry, 37:17773-17783, 1998 Cited by PubMed: 9922143 DOI: 10.1021/bi9816958 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation