1BZJ
Human ptp1b complexed with tpicooh
Summary for 1BZJ
Entry DOI | 10.2210/pdb1bzj/pdb |
Descriptor | PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE), 6-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBOXYLIC ACID (3 entities in total) |
Functional Keywords | phosphorylation, inhibitor complex, protein tyrosine phosphatase, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031 |
Total number of polymer chains | 1 |
Total formula weight | 34891.54 |
Authors | Groves, M.R.,Yao, Z.-J.,Barford Jr., D.T.B. (deposition date: 1998-10-29, release date: 1999-02-16, Last modification date: 2023-08-09) |
Primary citation | Groves, M.R.,Yao, Z.-J.,Roller, P.P.,Burke Jr., T.R.,Barford, D. Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics. Biochemistry, 37:17773-17783, 1998 Cited by PubMed: 9922143DOI: 10.1021/bi9816958 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)