1L8G
Crystal structure of PTP1B complexed with 7-(1,1-Dioxo-1H-benzo[d]isothiazol-3-yloxymethyl)-2-(oxalyl-amino)-4,7-dihydro-5H-thieno[2,3-c]pyran-3-carboxylic acid
Summary for 1L8G
Entry DOI | 10.2210/pdb1l8g/pdb |
Related | 1c83 |
Descriptor | PROTEIN-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1, 7-(1,1-DIOXO-1H-BENZO[D]ISOTHIAZOL-3-YLOXYMETHYL)-2-(OXALYL-AMINO)-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID (3 entities in total) |
Functional Keywords | protein-inhibitor, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031 |
Total number of polymer chains | 1 |
Total formula weight | 37832.08 |
Authors | Iversen, L.F.,Andersen, H.S.,Moller, K.B.,Olsen, O.H.,Peters, G.H.,Branner, S.,Mortensen, S.B.,Hansen, T.K.,Lau, J.,Ge, Y.,Holsworth, D.D.,Newman, M.J.,Moller, N.P.H. (deposition date: 2002-03-20, release date: 2002-05-08, Last modification date: 2024-02-14) |
Primary citation | Iversen, L.F.,Andersen, H.S.,Moller, K.B.,Olsen, O.H.,Peters, G.H.,Branner, S.,Mortensen, S.B.,Hansen, T.K.,Lau, J.,Ge, Y.,Holsworth, D.D.,Newman, M.J.,Hundahl Moller, N.P. Steric hindrance as a basis for structure-based design of selective inhibitors of protein-tyrosine phosphatases. Biochemistry, 40:14812-14820, 2001 Cited by PubMed: 11732900DOI: 10.1021/bi011389l PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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