1L8G
Crystal structure of PTP1B complexed with 7-(1,1-Dioxo-1H-benzo[d]isothiazol-3-yloxymethyl)-2-(oxalyl-amino)-4,7-dihydro-5H-thieno[2,3-c]pyran-3-carboxylic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | PROTEIN-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1 | polymer | 321 | 37365.6 | 1 | UniProt (P18031) Pfam (PF00102) | Homo sapiens (human) | PTP1B, PROTEIN-TYROSINE PHOSPHATASE 1B |
| 2 | B (A) | 7-(1,1-DIOXO-1H-BENZO[D]ISOTHIAZOL-3-YLOXYMETHYL)-2-(OXALYL-AMINO)-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID | non-polymer | 466.4 | 1 | Chemie (DBD) PubChem (4628829) | |||
| 3 | C (A) | water | water | 18.0 | 136 | Chemie (HOH) |
Sequence modifications
A: 1 - 321 (UniProt: P18031)
| PDB | External Database | Details |
|---|---|---|
| Thr 151 | Ser 151 | conflict |
| Asp 252 | Glu 252 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37365.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 466.4 | |
| All* | Total formula weight | 37832.1 |
