1ONY
Oxalyl-Aryl-Amino Benzoic Acid inhibitors of PTP1B, compound 17
Summary for 1ONY
Entry DOI | 10.2210/pdb1ony/pdb |
Related | 1NL9 1NNY 1No6 1NZ7 1onz |
Descriptor | Protein-tyrosine phosphatase, non-receptor type 1, 2-{[2-(2-CARBAMOYL-VINYL)-4-(2-METHANESULFONYLAMINO-2-PENTYLCARBAMOYL-ETHYL)-PHENYL]-OXALYL-AMINO}-BENZOIC ACID (3 entities in total) |
Functional Keywords | protein tyrosine phosphatase, oxalyl-aryl-amino benzoic acid inhibitor, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031 |
Total number of polymer chains | 1 |
Total formula weight | 37954.27 |
Authors | Liu, G.,Szczepankiewicz, B.G.,Pei, Z.,Janowich, D.A.,Xin, Z.,Hadjuk, P.J.,Abad-Zapatero, C.,Liang, H.,Hutchins, C.W.,Fesik, S.W.,Ballaron, S.J.,Stashko, M.A.,Lubben, T.,Mika, A.K.,Zinker, B.A.,Trevillyan, J.M.,Jirousek, M.R. (deposition date: 2003-03-02, release date: 2003-05-20, Last modification date: 2023-08-16) |
Primary citation | Liu, G.,Szczepankiewicz, B.G.,Pei, Z.,Janowich, D.A.,Xin, Z.,Hadjuk, P.J.,Abad-Zapatero, C.,Liang, H.,Hutchins, C.W.,Fesik, S.W.,Ballaron, S.J.,Stashko, M.A.,Lubben, T.,Mika, A.K.,Zinker, B.A.,Trevillyan, J.M.,Jirousek, M.R. Discovery and Structure-Activity Relationship of Oxalylarylaminobenzoic Acids as Inhibitors of Protein Tyrosine Phosphatase 1B J.Med.Chem., 46:2093-2103, 2003 Cited by PubMed: 12747781DOI: 10.1021/jm0205696 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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