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1T4J

Allosteric Inhibition of Protein Tyrosine Phosphatase 1B

Summary for 1T4J
Entry DOI10.2210/pdb1t4j/pdb
Related1PTY 1T48 1T49 2HNP
DescriptorProtein-tyrosine phosphatase, non-receptor type 1, 3-(3,5-DIBROMO-4-HYDROXY-BENZOYL)-2-ETHYL-BENZOFURAN-6-SULFONIC ACID [4-(THIAZOL-2-YLSULFAMOYL)-PHENYL]-AMIDE (2 entities in total)
Functional Keywordsallosteric inhibition protein tyrosine phosphatase 1b, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationEndoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031
Total number of polymer chains1
Total formula weight35462.01
Authors
Wiesmann, C.,Barr, K.J.,Kung, J.,Zhu, J.,Shen, W.,Fahr, B.J.,Zhong, M.,Taylor, L.,Randal, M.,McDowell, R.S.,Hansen, S.K. (deposition date: 2004-04-29, release date: 2004-07-20, Last modification date: 2024-02-14)
Primary citationWiesmann, C.,Barr, K.J.,Kung, J.,Zhu, J.,Erlanson, D.A.,Shen, W.,Fahr, B.J.,Zhong, M.,Taylor, L.,Randal, M.,McDowell, R.S.,Hansen, S.K.
Allosteric inhibition of protein tyrosine phosphatase 1B
Nat.Struct.Mol.Biol., 11:730-737, 2004
Cited by
PubMed: 15258570
DOI: 10.1038/nsmb803
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.7 Å)
Structure validation

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