1BZC
HUMAN PTP1B CATALYTIC DOMAIN COMPLEXED WITH TPI
Summary for 1BZC
Entry DOI | 10.2210/pdb1bzc/pdb |
Descriptor | PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE), 4-CARBAMOYL-4-{[6-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBONYL]-AMINO}-BUTYRIC ACID (3 entities in total) |
Functional Keywords | hydrolase(phosphorylation), tyrosine phosphatase, inhibitor complex, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031 |
Total number of polymer chains | 1 |
Total formula weight | 37795.93 |
Authors | Groves, M.R.,Yao, Z.J.,Jr Burke, T.R.,Barford, D. (deposition date: 1998-10-27, release date: 1999-02-16, Last modification date: 2023-08-09) |
Primary citation | Groves, M.R.,Yao, Z.J.,Roller, P.P.,Burke Jr., T.R.,Barford, D. Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics. Biochemistry, 37:17773-17783, 1998 Cited by PubMed: 9922143DOI: 10.1021/bi9816958 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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