1LQF
Structure of PTP1b in Complex with a Peptidic Bisphosphonate Inhibitor
Summary for 1LQF
Entry DOI | 10.2210/pdb1lqf/pdb |
Descriptor | protein-tyrosine phosphatase, non-receptor type 1, N-BENZOYL-L-GLUTAMYL-[4-PHOSPHONO(DIFLUOROMETHYL)]-L-PHENYLALANINE-[4-PHOSPHONO(DIFLUORO-METHYL)]-L-PHENYLALANINEAMIDE (3 entities in total) |
Functional Keywords | phosphatase, phosphonates, diabetes, inhibitor, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031 |
Total number of polymer chains | 4 |
Total formula weight | 141023.76 |
Authors | Asante-Appiah, E.,Patel, S.,Dufresne, C.,Scapin, G. (deposition date: 2002-05-10, release date: 2002-07-24, Last modification date: 2023-08-16) |
Primary citation | Asante-Appiah, E.,Patel, S.,Dufresne, C.,Roy, P.,Wang, Q.,Patel, V.,Friesen, R.W.,Ramachandran, C.,Becker, J.W.,Leblanc, Y.,Kennedy, B.P.,Scapin, G. The structure of PTP-1B in complex with a peptide inhibitor reveals an alternative binding mode for bisphosphonates. Biochemistry, 41:9043-9051, 2002 Cited by PubMed: 12119018DOI: 10.1021/bi0259554 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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