1LQF
Structure of PTP1b in Complex with a Peptidic Bisphosphonate Inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | protein-tyrosine phosphatase, non-receptor type 1 | polymer | 295 | 34451.4 | 4 | UniProt (P18031) Pfam (PF00102) | Homo sapiens (human) | PTP1B, Protein Tyrosine Phosphatase 1B |
| 2 | E, F, G, H (A, B, C, D) | N-BENZOYL-L-GLUTAMYL-[4-PHOSPHONO(DIFLUOROMETHYL)]-L-PHENYLALANINE-[4-PHOSPHONO(DIFLUORO-METHYL)]-L-PHENYLALANINEAMIDE | non-polymer | 804.6 | 4 | Chemie (BGD) | |||
| 3 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 528 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 501 - 783 (UniProt: P18031)
| PDB | External Database | Details |
|---|---|---|
| Met 489 | - | see remark 999 |
| Asp 490 | - | see remark 999 |
| Tyr 491 | - | see remark 999 |
| Lys 492 | - | see remark 999 |
| Asp 493 | - | see remark 999 |
| Asp 494 | - | see remark 999 |
| Asp 495 | - | see remark 999 |
| Asp 496 | - | see remark 999 |
| Lys 497 | - | see remark 999 |
| Leu 498 | - | see remark 999 |
| Glu 499 | - | see remark 999 |
| Phe 500 | - | see remark 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 137805.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 3218.3 | |
| All* | Total formula weight | 141023.8 |
