1PA1

Crystal structure of the C215D mutant of protein tyrosine phosphatase 1B

Summary for 1PA1

Entry DOI	10.2210/pdb1pa1/pdb
Descriptor	Protein-tyrosine phosphatase, non-receptor type 1, MAGNESIUM ION, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	phosphatase, catalytic loop, active-site mutant, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031
Total number of polymer chains	1
Total formula weight	36511.44
Authors	Romsicki, Y.,Scapin, G.,Beaulieu-Audy, V.,Patel, S.B.,Becker, J.W.,Kennedy, B.,Asante-Appiah, E. (deposition date: 2003-05-13, release date: 2003-08-05, Last modification date: 2023-08-16)
Primary citation	Romsicki, Y.,Scapin, G.,Beaulieu-Audy, V.,Patel, S.,Becker, J.W.,Kennedy, B.P.,Asante-Appiah, E. Functional characterization and crystal structure of the C215D mutant of protein-tyrosine phosphatase-1B J.Biol.Chem., 278:29009-29015, 2003 Cited by PubMed: 12748196 DOI: 10.1074/jbc.M303817200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation