1PA1
Crystal structure of the C215D mutant of protein tyrosine phosphatase 1B
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Protein-tyrosine phosphatase, non-receptor type 1 | polymer | 310 | 36250.1 | 1 | UniProt (P18031) Pfam (PF00102) | Homo sapiens (human) | Protein-tyrosine phosphatase 1B, PTP-1B |
| 2 | B, C (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 3 | D, E, F, G, H... (A) | CHLORIDE ION | non-polymer | 35.5 | 6 | Chemie (CL) | |||
| 4 | J (A) | water | water | 18.0 | 325 | Chemie (HOH) |
Sequence modifications
A: 501 - 798 (UniProt: P18031)
| PDB | External Database | Details |
|---|---|---|
| Met 489 | - | cloning artifact |
| Asp 490 | - | cloning artifact |
| Tyr 491 | - | cloning artifact |
| Lys 492 | - | cloning artifact |
| Asp 493 | - | cloning artifact |
| Asp 494 | - | cloning artifact |
| Asp 495 | - | cloning artifact |
| Asp 496 | - | cloning artifact |
| Lys 497 | - | cloning artifact |
| Leu 498 | - | cloning artifact |
| Glu 499 | - | cloning artifact |
| Phe 500 | - | cloning artifact |
| Asp 715 | Cys 215 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36250.1 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 261.3 | |
| All* | Total formula weight | 36511.4 |
