Crystal structure of L100I mutant HIV-1 reverse transcriptase in complex with UC-781

Summary for 1S1T

Related1VRT 1RTH 1VRU 1RTI 1RTJ 1REV 1RT1 1RT2 1KLM 1RT3 1RT4 1RT5 1RT6 1RT7 1C0T 1C0U 1C1B 1C1C 1DTQ 1DTT 1EP4 1FK9 1FKO 1FKP 1JLA 1JLB 1JLC 1JLE 1JLF 1JLG 1JKH 1JLQ 1LW0 1LW2 1LWC 1LWE 1LWF 1S1U 1S1V 1S1W 1S1X
DescriptorReverse transcriptase, PHOSPHATE ION, 2-METHYL-FURAN-3-CARBOTHIOIC ACID [4-CHLORO-3-(3-METHYL-BUT-2-ENYLOXY)-PHENYL]-AMIDE, ... (5 entities in total)
Functional Keywordshiv-1 reverse transcriptase, aids, nnrti, uc-781, drug resistance mutations, transferase
Biological sourceHuman immunodeficiency virus 1
Cellular locationMatrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential) P04585 P04585
Total number of polymer chains2
Total molecular weight116519.79
Ren, J.,Nichols, C.E.,Chamberlain, P.P.,Stammers, D.K. (deposition date: 2004-01-07, release date: 2004-06-29, Last modification date: 2011-07-13)
Primary citation
Ren, J.,Nichols, C.E.,Chamberlain, P.P.,Weaver, K.L.,Short, S.A.,Stammers, D.K.
Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors
J.Mol.Biol., 336:569-578, 2004
PubMed: 15095972 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2003.12.055
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.206201.0%5.3%5.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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