1LWC

CRYSTAL STRUCTURE OF M184V MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE

Summary for 1LWC
Related1C0T 1C0U 1C1B 1C1C 1DTQ 1DTT 1EP4 1FK9 1FKO 1FKP 1JKH 1JLA 1JLB 1JLC 1JLE 1JLF 1JLG 1JLQ 1KLM 1LW0 1LW2 1LWE 1LWF 1REV 1RT1 1RT2 1RT3 1RT4 1RT5 1RT6 1RT7 1RTH 1RTI 1RTJ 1VRT 1VRU
DescriptorHIV-1 REVERSE TRANSCRIPTASE, PHOSPHATE ION, 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE, ... (5 entities in total)
Functional Keywordshiv-1 reverse transcriptase, aids, azt, 3tc, nrti, nevirapine, drug resistance mutations, transferase
Biological sourceHuman immunodeficiency virus 1
More
Cellular locationMatrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 P04585
Total number of polymer chains2
Total formula weight116386.11
Authors
Ren, J.,Chamberlain, P.P.,Nichols, C.E.,Douglas, L.,Stuart, D.I.,Stammers, D.K. (deposition date: 2002-05-31, release date: 2002-10-30, Last modification date: 2011-07-13)
Primary citationChamberlain, P.P.,Douglas, L.,Larder, B.A.,Lennerstrand, J.,Nichols, C.E.,Ren, J.,Stammers, D.K.,Stuart, D.I.
Crystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215.
J.Virol., 76:10015-10019, 2002
PubMed: 12208978
DOI: 110.1128/JVI.76.19.10015-10019.2002
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.62 Å)
Structure validation
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PDB entries from 2021-06-09