1LWC

CRYSTAL STRUCTURE OF M184V MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE

Summary for 1LWC

Related1VRT 1RTH 1VRU 1RTI 1RTJ 1REV 1RT1 1RT2 1KLM 1RT3 1RT4 1RT5 1RT6 1RT7 1C0T 1C0U 1C1B 1C1C 1DTQ 1DTT 1EP4 1FK9 1FKO 1FKP 1JLA 1JLB 1JLC 1JLE 1JLF 1JLG 1JKH 1JLQ 1LW0 1LW2 1LWE 1LWF
DescriptorHIV-1 REVERSE TRANSCRIPTASE, PHOSPHATE ION, 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE, ... (5 entities in total)
Functional Keywordshiv-1 reverse transcriptase, aids, azt, 3tc, nrti, nevirapine, drug resistance mutations, transferase
Biological sourceHuman immunodeficiency virus 1
Cellular locationMatrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential) P04585 P04585
Total number of polymer chains2
Total molecular weight116386.11
Authors
Ren, J.,Chamberlain, P.P.,Nichols, C.E.,Douglas, L.,Stuart, D.I.,Stammers, D.K. (deposition date: 2002-05-31, release date: 2002-10-30, Last modification date: 2011-07-13)
Primary citation
Chamberlain, P.P.,Ren, J.,Nichols, C.E.,Douglas, L.,Lennerstrand, J.,Larder, B.A.,Stuart, D.I.,Stammers, D.K.
Crystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215.
J.Virol., 76:10015-10019, 2002
PubMed: 12208978 (PDB entries with the same primary citation)
DOI: 10.1128/JVI.76.19.10015-10019.2002
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.62 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers251.1%9.2%4.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload