1DTQ
CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH PETT-1 (PETT131A94)
Summary for 1DTQ
Entry DOI | 10.2210/pdb1dtq/pdb |
Related | 1c0t 1c0u 1c1b 1c1c 1DTT 1klm 1rev 1rt1 1rt2 1rt3 1rt4 1rt5 1rt6 1rt7 1rth 1rti 1rtj 1rtv 1vru |
Descriptor | HIV-1 RT A-CHAIN, HIV-1 RT B-CHAIN, N-[[3-FLUORO-4-ETHOXY-PYRID-2-YL]ETHYL]-N'-[5-NITRILOMETHYL-PYRIDYL]-THIOUREA, ... (4 entities in total) |
Functional Keywords | hiv-1 reverse transcriptase aids, non-nucleoside inhibitor, drug design, hydrolase-transferase complex, hydrolase/transferase |
Biological source | Human immunodeficiency virus 1 More |
Cellular location | Matrix protein p17: Virion . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585 P04585 |
Total number of polymer chains | 2 |
Total formula weight | 116339.39 |
Authors | Ren, J.,Diprose, J.,Warren, J.,Esnouf, R.M.,Bird, L.E.,Ikemizu, S.,Slater, M.,Milton, J.,Balzarini, J.,Stuart, D.I.,Stammers, D.K. (deposition date: 2000-01-13, release date: 2000-03-20, Last modification date: 2014-11-12) |
Primary citation | Ren, J.,Diprose, J.,Warren, J.,Esnouf, R.M.,Bird, L.E.,Ikemizu, S.,Slater, M.,Milton, J.,Balzarini, J.,Stuart, D.I.,Stammers, D.K. Phenylethylthiazolylthiourea (PETT) non-nucleoside inhibitors of HIV-1 and HIV-2 reverse transcriptases. Structural and biochemical analyses. J.Biol.Chem., 275:5633-5639, 2000 Cited by PubMed: 10681546DOI: 10.1074/jbc.275.8.5633 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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