1C1B

CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GCA-186

Summary for 1C1B

• Entry DOI: 10.2210/pdb1c1b/pdb
• Related: 1C1C 1c0t 1c0u 1klm 1rev 1rt1 1rt2 1rt3 1rt4 1rt5 1rt6 1rt7 1rth 1rti 1rtj 1rtv 1vru
• Descriptor: HIV-1 REVERSE TRANSCRIPTASE (A-CHAIN), HIV-1 REVERSE TRANSCRIPTASE (B-CHAIN), 6-(3',5'-DIMETHYLBENZYL)-1-ETHOXYMETHYL-5-ISOPROPYLURACIL, ... (4 entities in total)
• Functional Keywords: hiv-1 reverse transcriptase, aids, non-nucleoside inhibitor, drug design, transferase
• Biological source: Human immunodeficiency virus 1; More
• Cellular location: Matrix protein p17: Virion . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585 P04585
• Total number of polymer chains: 2
• Total formula weight: 116282.38

Authors

Hopkins, A.L.,Ren, J.,Tanaka, H.,Baba, B.,Okamato, M.,Stuart, D.I.,Stammers, D.K. (deposition date: 1999-07-21, release date: 2000-07-21, Last modification date: 2014-11-12)

• Primary citation: Hopkins, A.L.,Ren, J.,Tanaka, H.,Baba, M.,Okamato, M.,Stuart, D.I.,Stammers, D.K.; Design of MKC-442 (emivirine) analogues with improved activity against drug-resistant HIV mutants.; J.Med.Chem., 42:4500-4505, 1999; PubMed: 10579814; DOI: 10.1021/jm990192c

Experimental method

X-RAY DIFFRACTION (2.5 Å)