1RT3
AZT DRUG RESISTANT HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH 1051U91
Summary for 1RT3
Entry DOI | 10.2210/pdb1rt3/pdb |
Descriptor | HIV-1 REVERSE TRANSCRIPTASE, 6,11-DIHYDRO-11-ETHYL-6-METHYL-9-NITRO-5H-PYRIDO[2,3-B][1,5]BENZODIAZEPIN-5-ONE (3 entities in total) |
Functional Keywords | nucleotidyltransferase, hiv-1 reverse transcriptase, aids, nucleoside inhibitor, drug resistance mutation |
Biological source | Human immunodeficiency virus 1 More |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 P04585 |
Total number of polymer chains | 2 |
Total formula weight | 116391.37 |
Authors | Ren, J.,Stammers, D.K.,Stuart, D.I. (deposition date: 1998-06-29, release date: 1999-02-16, Last modification date: 2023-08-09) |
Primary citation | Ren, J.,Esnouf, R.M.,Hopkins, A.L.,Jones, E.Y.,Kirby, I.,Keeling, J.,Ross, C.K.,Larder, B.A.,Stuart, D.I.,Stammers, D.K. 3'-Azido-3'-deoxythymidine drug resistance mutations in HIV-1 reverse transcriptase can induce long range conformational changes. Proc.Natl.Acad.Sci.USA, 95:9518-9523, 1998 Cited by PubMed: 9689112DOI: 10.1073/pnas.95.16.9518 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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