1KLM

HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH BHAP U-90152

Summary for 1KLM
DescriptorHIV-1 REVERSE TRANSCRIPTASE, (1-(5-METHANSULPHONAMIDO-1H-INDOL-2-YL-CARBONYL)4-[METHYLAMINO)PYRIDINYL]PIPERAZINE, ... (4 entities in total)
Functional Keywordsaids, hiv-1, endonuclease, rna-directed dna polymerase, hiv-1 reverse transcriptase, bhap u-90152, drug, nucleotidyltransferase
Biological sourceHuman immunodeficiency virus 1
More
Cellular locationMatrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 P04585
Total number of polymer chains2
Total formula weight116450.56
Authors
Ren, J.,Esnouf, R.M.,Stammers, D.K.,Stuart, D.I. (deposition date: 1997-03-17, release date: 1998-03-18, Last modification date: 2012-07-18)
Primary citationEsnouf, R.M.,Hopkins, A.L.,Jones, E.Y.,Ren, J.,Ross, C.K.,Stammers, D.K.,Stuart, D.I.
Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor.
Proc.Natl.Acad.Sci.USA, 94:3984-3989, 1997
PubMed: 9108091
DOI: 110.1073/pnas.94.8.3984
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.65 Å)
Structure validation
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PDB entries from 2021-06-09