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1C1C

CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH TNK-6123

Summary for 1C1C
Entry DOI10.2210/pdb1c1c/pdb
Related1C0T 1C0U 1C1B 1KLM 1REV 1RT1 1RT2 1RT3 1RT4 1RT5 1RT6 1RT7 1RTH 1RTI 1RTJ 1RTV 1VRU
DescriptorHIV-1 REVERSE TRANSCRIPTASE (A-CHAIN), HIV-1 REVERSE TRANSCRIPTASE (B-CHAIN), 6-(cyclohexylsulfanyl)-1-(ethoxymethyl)-5-(1-methylethyl)pyrimidine-2,4(1H,3H)-dione, ... (4 entities in total)
Functional Keywordshiv-1 reverse transcriptase, aids, non-nucleoside inhibitor, drug design, transferase
Biological sourceHuman immunodeficiency virus 1
More
Cellular locationMatrix protein p17: Virion . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585 P04585
Total number of polymer chains2
Total formula weight116320.45
Authors
Hopkins, A.L.,Ren, J.,Tanaka, H.,Baba, M.,Okamato, M.,Stuart, D.I.,Stammers, D.K. (deposition date: 1999-07-21, release date: 2000-07-21, Last modification date: 2014-11-12)
Primary citationHopkins, A.L.,Ren, J.,Tanaka, H.,Baba, M.,Okamato, M.,Stuart, D.I.,Stammers, D.K.
Design of MKC-442 (emivirine) analogues with improved activity against drug-resistant HIV mutants.
J.Med.Chem., 42:4500-4505, 1999
Cited by
PubMed: 10579814
DOI: 10.1021/jm990192c
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

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