1KLM
HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH BHAP U-90152
Summary for 1KLM
Entry DOI | 10.2210/pdb1klm/pdb |
Descriptor | HIV-1 REVERSE TRANSCRIPTASE, (1-(5-METHANSULPHONAMIDO-1H-INDOL-2-YL-CARBONYL)4-[METHYLAMINO)PYRIDINYL]PIPERAZINE, ... (4 entities in total) |
Functional Keywords | aids, hiv-1, endonuclease, rna-directed dna polymerase, hiv-1 reverse transcriptase, bhap u-90152, drug, nucleotidyltransferase |
Biological source | Human immunodeficiency virus 1 More |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 P04585 |
Total number of polymer chains | 2 |
Total formula weight | 116450.56 |
Authors | Ren, J.,Esnouf, R.M.,Stammers, D.K.,Stuart, D.I. (deposition date: 1997-03-17, release date: 1998-03-18, Last modification date: 2024-04-03) |
Primary citation | Esnouf, R.M.,Ren, J.,Hopkins, A.L.,Ross, C.K.,Jones, E.Y.,Stammers, D.K.,Stuart, D.I. Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor. Proc.Natl.Acad.Sci.USA, 94:3984-3989, 1997 Cited by PubMed: 9108091DOI: 10.1073/pnas.94.8.3984 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
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