1LWC

CRYSTAL STRUCTURE OF M184V MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	HIV-1 REVERSE TRANSCRIPTASE	polymer	560	64562.9	1	UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) In PDB	Human immunodeficiency virus 1	HIV-1 RT
2	B	HIV-1 REVERSE TRANSCRIPTASE	polymer	440	51367.0	1	UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) In PDB	Human immunodeficiency virus 1	HIV-1 RT
3	A	PHOSPHATE ION	non-polymer		95.0	2	Chemie (PO4)
4	A	11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE	non-polymer		266.3	1	Chemie (NVP)
5		water	water		18.0	18	Chemie (HOH)

Sequence modifications

A: 1 - 560 (UniProt: P04585)

PDB	External Database	Details
Val 184	Met 339	engineered mutation
Csd 280	Cys 435	modified residue

B: 1 - 440 (UniProt: P04585)

PDB	External Database	Details
Val 184	Met 339	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	115929.9
Non-Polymers*	Number of molecules	3
	Total formula weight	456.2
All*	Total formula weight	116386.1

*Water molecules are not included.