1JLQ
CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH 739W94
Summary for 1JLQ
Entry DOI | 10.2210/pdb1jlq/pdb |
Related | 1C0T 1C0U 1C1B 1C1C 1DTQ 1DTT 1EP4 1FK9 1FKO 1FKP 1JKH 1JLA 1JLB 1JLC 1JLE 1JLF 1JLG 1KLM 1REV 1RT1 1RT2 1RT3 1RT4 1RT5 1RT6 1RT7 1RTH 1RTI 1RTJ 1VRT 1VRU |
Descriptor | HIV-1 RT, A-CHAIN, HIV-1 RT, B-CHAIN, 2-AMINO-6-(3,5-DIMETHYLPHENYL)SULFONYLBENZONITRILE (3 entities in total) |
Functional Keywords | hiv-1 reverse transcriptase, aids, non-nucleoside inhibitor, 739w94, drug design, transferase |
Biological source | HIV-1 M:B_HXB2R More |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585 P04585 |
Total number of polymer chains | 2 |
Total formula weight | 116280.35 |
Authors | Ren, J.,Stuart, D.I.,Stammers, D.K. (deposition date: 2001-07-16, release date: 2001-08-22, Last modification date: 2022-12-21) |
Primary citation | Chan, J.H.,Hong, J.S.,Hunter III, R.N.,Orr, G.F.,Cowan, J.R.,Sherman, D.B.,Sparks, S.M.,Reitter, B.E.,Andrews III., C.W.,Hazen, R.J.,St Clair, M.,Boone, L.R.,Ferris, R.G.,Creech, K.L.,Roberts, G.B.,Short, S.A.,Weaver, K.,Ott, R.J.,Ren, J.,Hopkins, A.,Stuart, D.I.,Stammers, D.K. 2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1. J.Med.Chem., 44:1866-1882, 2001 Cited by PubMed: 11384233DOI: 10.1021/jm0004906 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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