1JLQ

CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH 739W94

Summary for 1JLQ
Related1C0T 1C0U 1C1B 1C1C 1DTQ 1DTT 1EP4 1FK9 1FKO 1FKP 1JKH 1JLA 1JLB 1JLC 1JLE 1JLF 1JLG 1KLM 1REV 1RT1 1RT2 1RT3 1RT4 1RT5 1RT6 1RT7 1RTH 1RTI 1RTJ 1VRT 1VRU
DescriptorHIV-1 RT, A-CHAIN, HIV-1 RT, B-CHAIN, 2-AMINO-6-(3,5-DIMETHYLPHENYL)SULFONYLBENZONITRILE (3 entities in total)
Functional Keywordshiv-1 reverse transcriptase, aids, non-nucleoside inhibitor, 739w94, drug design, transferase
Biological sourceHIV-1 M:B_HXB2R
More
Cellular locationGag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585 P04585
Total number of polymer chains2
Total formula weight116280.35
Authors
Ren, J.,Stuart, D.I.,Stammers, D.K. (deposition date: 2001-07-16, release date: 2001-08-22, Last modification date: 2018-01-31)
Primary citationAndrews III., C.W.,Boone, L.R.,Chan, J.H.,Cowan, J.R.,Creech, K.L.,Ferris, R.G.,Hazen, R.J.,Hong, J.S.,Hopkins, A.,Hunter III, R.N.,Orr, G.F.,Ott, R.J.,Reitter, B.E.,Ren, J.,Roberts, G.B.,Sherman, D.B.,Short, S.A.,Sparks, S.M.,St Clair, M.,Stammers, D.K.,Stuart, D.I.,Weaver, K.
2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1.
J.Med.Chem., 44:1866-1882, 2001
PubMed: 11384233
DOI: 110.1021/jm0004906
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3 Å)
Structure validation
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178747

PDB entries from 2021-06-09