1JLE

CRYSTAL STRUCTURE OF Y188C MUTANT HIV-1 REVERSE TRANSCRIPTASE

Summary for 1JLE

Related1VRT 1RTH 1VRU 1RTI 1RTJ 1REV 1RT1 1RT2 1KLM 1RT3 1RT4 1RT5 1RT6 1RT7 1C0T 1C0U 1C1B 1C1C 1DTQ 1DTT 1EP4 1FK9 1FKO 1FKP 1JKH 1JLB 1JLC 1JLF 1JLA 1JLQ 1JLG
DescriptorHIV-1 RT, A-CHAIN, HIV-1 RT, B-CHAIN (3 entities in total)
Functional Keywordshiv-1 reverse transcriptase, aids, non-nucleoside inhibitor, drug resistance mutations, drug design, transferase
Biological sourceHIV-1 M:B_HXB2R
Cellular locationMatrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential) P04585 P04585
Total number of polymer chains2
Total molecular weight115905.93
Authors
Ren, J.,Nichols, C.,Bird, L.,Chamberlain, P.,Weaver, K.,Short, S.,Stuart, D.I.,Stammers, D.K. (deposition date: 2001-07-16, release date: 2001-10-03, Last modification date: 2011-07-13)
Primary citation
Ren, J.,Nichols, C.,Bird, L.,Chamberlain, P.,Weaver, K.,Short, S.,Stuart, D.I.,Stammers, D.K.
Structural mechanisms of drug resistance for mutations at codons 181 and 188 in HIV-1 reverse transcriptase and the improved resilience of second generation non-nucleoside inhibitors.
J.Mol.Biol., 312:795-805, 2001
PubMed: 11575933 (PDB entries with the same primary citation)
DOI: 10.1006/jmbi.2001.4988
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.8 Å)
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers424.7%12.0%4.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 1jle
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Molmil generated image of 1jle
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Molmil generated image of 1jle
rotated about y axis by 90°