1FK9

CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DMP-266(EFAVIRENZ)

Summary for 1FK9

Related1rtv 1rth 1vru 1rti 1rtj 1rev 1rt1 1rt2 1klm 1rt3 1rt4 1rt5 1rt6 1rt7 1c0t 1c0u 1c1b 1c1c 1dtq 1dtt 1ep4
DescriptorHIV-1 RT, A-CHAIN, HIV-1 RT, B-CHAIN, (-)-6-CHLORO-4-CYCLOPROPYLETHYNYL-4-TRIFLUOROMETHYL-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONE, ... (4 entities in total)
Functional Keywordshiv-1 reverse transcriptase, aids, non-nucleoside inhibitor, dmp-266, efavirenz, drug design, transferase
Biological sourceHuman immunodeficiency virus 1
Cellular locationGag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion  P04585 P04585
Total number of polymer chains2
Total molecular weight114498.55
Authors
Ren, J.,Milton, J.,Weaver, K.L.,Short, S.A.,Stuart, D.I.,Stammers, D.K. (deposition date: 2000-08-09, release date: 2000-11-03, Last modification date: 2017-02-01)
Primary citation
Ren, J.,Milton, J.,Weaver, K.L.,Short, S.A.,Stuart, D.I.,Stammers, D.K.
Structural basis for the resilience of efavirenz (DMP-266) to drug resistance mutations in HIV-1 reverse transcriptase.
STRUCTURE FOLD.DES., 8:1089-1094, 2000
PubMed: 11080630 (PDB entries with the same primary citation)
DOI: 10.1016/S0969-2126(00)00513-X
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.5 Å)
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers271.8%5.6%6.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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