1FKP

CRYSTAL STRUCTURE OF NNRTI RESISTANT K103N MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE

Summary for 1FKP

Related1rtv 1rth 1vru 1rti 1rtj 1rev 1rt1 1rt2 1klm 1rt3 1rt4 1rt5 1rt6 1rt7 1c0t 1c0u 1c1b 1c1c 1dtq 1dtt 1ep4 1fk9 1fko
DescriptorHIV-1 RT, A-CHAIN, HIV-1 RT, B-CHAIN, 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE (3 entities in total)
Functional Keywordshiv-1 reverse transcriptase, aids, non-nucleoside inhibitor, nevirapine, drug resistance mutation, drug design, transferase
Biological sourceHuman immunodeficiency virus 1
Cellular locationGag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion  P04585 P04585
Total number of polymer chains2
Total molecular weight114419.01
Authors
Ren, J.,Milton, J.,Weaver, K.L.,Short, S.A.,Stuart, D.I.,Stammers, D.K. (deposition date: 2000-08-10, release date: 2000-11-03, Last modification date: 2018-03-14)
Primary citation
Ren, J.,Milton, J.,Weaver, K.L.,Short, S.A.,Stuart, D.I.,Stammers, D.K.
Structural basis for the resilience of efavirenz (DMP-266) to drug resistance mutations in HIV-1 reverse transcriptase.
Structure Fold.Des., 8:1089-1094, 2000
PubMed: 11080630 (PDB entries with the same primary citation)
DOI: 10.1016/S0969-2126(00)00513-X
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.9 Å)
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers332.8%9.4%4.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 1fkp
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Molmil generated image of 1fkp
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Molmil generated image of 1fkp
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