1S1T
Crystal structure of L100I mutant HIV-1 reverse transcriptase in complex with UC-781
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Reverse transcriptase | polymer | 560 | 64594.9 | 1 | UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) | Human immunodeficiency virus 1 | HIV-1 RT |
| 2 | B (B) | Reverse transcriptase | polymer | 440 | 51399.0 | 1 | UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) | Human immunodeficiency virus 1 | HIV-1 RT |
| 3 | C, E (A, B) | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 4 | D (A) | 2-METHYL-FURAN-3-CARBOTHIOIC ACID [4-CHLORO-3-(3-METHYL-BUT-2-ENYLOXY)-PHENYL]-AMIDE | non-polymer | 335.8 | 1 | Chemie (UC1) | |||
| 5 | F, G (A, B) | water | water | 18.0 | 184 | Chemie (HOH) |
Sequence modifications
A: 1 - 560 (UniProt: P04585)
B: 1 - 440 (UniProt: P04585)
| PDB | External Database | Details |
|---|---|---|
| Ile 100 | Leu 255 | engineered mutation |
| Csd 280 | Cys 435 | modified residue |
| PDB | External Database | Details |
|---|---|---|
| Ile 100 | Leu 255 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 115994.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 525.8 | |
| All* | Total formula weight | 116519.8 |
