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2I35
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BU of 2i35 by Molmil
Crystal structure of rhombohedral crystal form of ground-state rhodopsin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PALMITIC ACID, RETINAL, ...
Authors:Stenkamp, R.E, Le Trong, I, Lodowski, D.T, Salom, D, Palczewski, K.
Deposit date:2006-08-17
Release date:2006-10-17
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Crystal structure of a photoactivated deprotonated intermediate of rhodopsin.
Proc.Natl.Acad.Sci.Usa, 103, 2006
7O7F
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BU of 7o7f by Molmil
Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist
Descriptor: C-C chemokine receptor type 5, C-C motif chemokine 5, Fab antibody fragment heavy chain, ...
Authors:Isaikina, P, Tsai, C.-J, Dietz, N.B, Pamula, F, Goldie, K.N, Schertler, G.F.X, Maier, T, Stahlberg, H, Deupi, X, Grzesiek, S.
Deposit date:2021-04-13
Release date:2021-06-30
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (3.15 Å)
Cite:Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist.
Sci Adv, 7, 2021
2I36
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BU of 2i36 by Molmil
Crystal structure of trigonal crystal form of ground-state rhodopsin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PALMITIC ACID, Rhodopsin, ...
Authors:Stenkamp, R.E, Le Trong, I, Lodowski, D.T, Salom, D, Palczewski, K.
Deposit date:2006-08-17
Release date:2006-10-17
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (4.1 Å)
Cite:Crystal structure of a photoactivated deprotonated intermediate of rhodopsin.
Proc.Natl.Acad.Sci.Usa, 103, 2006
5CXV
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BU of 5cxv by Molmil
Structure of the human M1 muscarinic acetylcholine receptor bound to antagonist Tiotropium
Descriptor: (1R,2R,4S,5S,7S)-7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane, 1,2-ETHANEDIOL, CHOLESTEROL HEMISUCCINATE, ...
Authors:Sun, B, Feng, D, Li, X, Kobilka, T.S, Kobilka, B.K.
Deposit date:2015-07-29
Release date:2016-03-09
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structures of the M1 and M4 muscarinic acetylcholine receptors.
Nature, 531, 2016
4LDE
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BU of 4lde by Molmil
Structure of beta2 adrenoceptor bound to BI167107 and an engineered nanobody
Descriptor: (2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate, 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one, Camelid Antibody Fragment, ...
Authors:Ring, A.M, Manglik, A, Kruse, A.C, Enos, M.D, Weis, W.I, Garcia, K.C, Kobilka, B.K.
Deposit date:2013-06-24
Release date:2013-09-25
Last modified:2024-11-27
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Adrenaline-activated structure of beta 2-adrenoceptor stabilized by an engineered nanobody.
Nature, 502, 2013
2I37
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BU of 2i37 by Molmil
Crystal structure of a photoactivated rhodopsin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Rhodopsin, ...
Authors:Lodowski, D.T, Stenkamp, R.E, Salom, D, Le Trong, I, Palczewski, K.
Deposit date:2006-08-17
Release date:2006-10-17
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (4.15 Å)
Cite:Crystal structure of a photoactivated deprotonated intermediate of rhodopsin.
Proc.Natl.Acad.Sci.Usa, 103, 2006
8RQQ
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BU of 8rqq by Molmil
In meso structure of the adenosine A2a G protein-coupled receptor, A2aR, in 7.10 monoacylglycerol
Descriptor: 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, 7.10 monoacylglycerol (R-form), 7.10 monoacylglycerol (S-form), ...
Authors:Smithers, L, Krawinski, P, Caffrey, M.
Deposit date:2024-01-19
Release date:2024-04-03
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:7.10 MAG. A Novel Host Monoacylglyceride for In Meso (Lipid Cubic Phase) Crystallization of Membrane Proteins.
Cryst.Growth Des., 24, 2024
5XJM
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BU of 5xjm by Molmil
Complex structure of angiotensin II type 2 receptor with Fab
Descriptor: FabH, FabL, Sar1, ...
Authors:Asada, H, Horita, S, Shimamura, T, Iwata, S.
Deposit date:2017-05-02
Release date:2018-07-11
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of the human angiotensin II type 2 receptor bound to an angiotensin II analog
Nat. Struct. Mol. Biol., 25, 2018
4LDL
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BU of 4ldl by Molmil
Structure of beta2 adrenoceptor bound to hydroxybenzylisoproterenol and an engineered nanobody
Descriptor: (2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate, 4-[(1R)-1-hydroxy-2-{[1-(4-hydroxyphenyl)-2-methylpropan-2-yl]amino}ethyl]benzene-1,2-diol, Camelid Antibody Fragment, ...
Authors:Ring, A.M, Manglik, A, Kruse, A.C, Enos, M.D, Weis, W.I, Garcia, K.C, Kobilka, B.K.
Deposit date:2013-06-24
Release date:2013-09-25
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Adrenaline-activated structure of beta 2-adrenoceptor stabilized by an engineered nanobody.
Nature, 502, 2013
8RLN
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BU of 8rln by Molmil
Crystal structure of human adenosine A2A receptor (construct A2A-PSB2-bRIL) complexed with the partial antagonist LUF5834 at the orthosteric pocket
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-azanyl-4-(4-hydroxyphenyl)-6-(1~{H}-imidazol-2-ylmethylsulfanyl)pyridine-3,5-dicarbonitrile, ...
Authors:Strater, N, Claff, T, Weisse, R.H, Muller, C.E.
Deposit date:2024-01-03
Release date:2024-06-19
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Structural Insights into Partial Activation of the Prototypic G Protein-Coupled Adenosine A 2A Receptor.
Acs Pharmacol Transl Sci, 7, 2024
5XR8
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BU of 5xr8 by Molmil
Crystal structure of the human CB1 in complex with agonist AM841
Descriptor: (6~{a}~{R},9~{R},10~{a}~{R})-9-(hydroxymethyl)-3-(8-isothiocyanato-2-methyl-octan-2-yl)-6,6-dimethyl-6~{a},7,8,9,10,10~{a}-hexahydrobenzo[c]chromen-1-ol, CHOLESTEROL, Cannabinoid receptor 1,Flavodoxin,Cannabinoid receptor 1, ...
Authors:Hua, T, Vemuri, K, Nikas, P.S, Laprairie, R.B, Wu, Y, Qu, L, Pu, M, Korde, A, Shan, J, Ho, J.H, Han, G.W, Ding, K, Li, X, Liu, H, Hanson, M.A, Zhao, S, Bohn, L.M, Makriyannis, A, Stevens, R.C, Liu, Z.J.
Deposit date:2017-06-07
Release date:2017-07-12
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Crystal structures of agonist-bound human cannabinoid receptor CB1.
Nature, 547, 2017
5D5A
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BU of 5d5a by Molmil
In meso in situ serial X-ray crystallography structure of the Beta2-adrenergic receptor at 100 K
Descriptor: (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol, 1,4-BUTANEDIOL, ACETAMIDE, ...
Authors:Huang, C.-Y, Olieric, V, Warshamanage, R, Liu, X, Kobilka, B, Kay Diederichs, K, Wang, M, Caffrey, M.
Deposit date:2015-08-10
Release date:2016-01-13
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.4826 Å)
Cite:In meso in situ serial X-ray crystallography of soluble and membrane proteins at cryogenic temperatures.
Acta Crystallogr D Struct Biol, 72, 2016
5DHH
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BU of 5dhh by Molmil
The crystal structure of nociceptin/orphanin FQ peptide receptor (NOP) in complex with SB-612111 (PSI Community Target)
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (5S,7S)-7-{[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl}-1-methyl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ol, OLEIC ACID, ...
Authors:Miller, R.L, Thompson, A.A, Trapella, C, Guerrini, R, Malfacini, D, Patel, N, Han, G.W, Cherezov, V, Calo, G, Katritch, V, Stevens, R.C, GPCR Network (GPCR)
Deposit date:2015-08-31
Release date:2015-10-21
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (3.004 Å)
Cite:The Importance of Ligand-Receptor Conformational Pairs in Stabilization: Spotlight on the N/OFQ G Protein-Coupled Receptor.
Structure, 23, 2015
5X7D
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BU of 5x7d by Molmil
Structure of beta2 adrenoceptor bound to carazolol and an intracellular allosteric antagonist
Descriptor: (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol, 1,4-BUTANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Liu, X, Ahn, S, Kahsai, A.W, Meng, K.-C, Latorraca, N.R, Pani, B, Venkatakrishnan, A.J, Masoudi, A, Weis, W.I, Dror, R.O, Chen, X, Lefkowitz, R.J, Kobilka, B.K.
Deposit date:2017-02-25
Release date:2017-08-16
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.703 Å)
Cite:Mechanism of intracellular allosteric beta 2AR antagonist revealed by X-ray crystal structure.
Nature, 548, 2017
1GZM
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BU of 1gzm by Molmil
Structure of Bovine Rhodopsin in a Trigonal Crystal Form
Descriptor: (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE, LAURYL DIMETHYLAMINE-N-OXIDE, ...
Authors:Li, J.
Deposit date:2002-05-24
Release date:2003-11-20
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure of Bovine Rhodopsin in a Trigonal Crystal Form
J.Mol.Biol., 343, 2004
7P02
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BU of 7p02 by Molmil
Human Neurokinin 1 receptor (NK1R) substance P Gs complex
Descriptor: Antibody fragment scFv16, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Thom, C, Ehrenmann, J, Vacca, S, Waltenspuhl, Y, Schoppe, J, Medalia, O, Pluckthun, A.
Deposit date:2021-06-29
Release date:2021-12-15
Last modified:2025-07-09
Method:ELECTRON MICROSCOPY (2.87 Å)
Cite:Structures of neurokinin 1 receptor in complex with G q and G s proteins reveal substance P binding mode and unique activation features.
Sci Adv, 7, 2021
7PIU
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BU of 7piu by Molmil
Cryo-EM structure of the agonist setmelanotide bound to the active melanocortin-4 receptor (MC4R) in complex with the heterotrimeric Gs protein at 2.6 A resolution.
Descriptor: CALCIUM ION, Camelid antibody fragment - nanobody 35, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Heyder, N.A, Schmidt, A, Kleinau, G, Hilal, T, Scheerer, P.
Deposit date:2021-08-23
Release date:2021-11-17
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (2.58 Å)
Cite:Structures of active melanocortin-4 receptor-Gs-protein complexes with NDP-alpha-MSH and setmelanotide.
Cell Res., 31, 2021
1HZX
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BU of 1hzx by Molmil
CRYSTAL STRUCTURE OF BOVINE RHODOPSIN
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HEPTANE-1,2,3-TRIOL, MERCURY (II) ION, ...
Authors:Teller, D.C, Okada, T, Behnke, C.A, Palczewski, K, Stenkamp, R.E.
Deposit date:2001-01-26
Release date:2001-07-04
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Advances in determination of a high-resolution three-dimensional structure of rhodopsin, a model of G-protein-coupled receptors (GPCRs).
Biochemistry, 40, 2001
1JFP
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BU of 1jfp by Molmil
Structure of bovine rhodopsin (dark adapted)
Descriptor: RETINAL, rhodopsin
Authors:Yeagle, P.L, Choi, G, Albert, A.D.
Deposit date:2001-06-21
Release date:2001-10-05
Last modified:2024-12-25
Method:SOLUTION NMR
Cite:Studies on the structure of the G-protein-coupled receptor rhodopsin including the putative G-protein binding site in unactivated and activated forms.
Biochemistry, 40, 2001
3NYA
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BU of 3nya by Molmil
Crystal structure of the human beta2 adrenergic receptor in complex with the neutral antagonist alprenolol
Descriptor: (2S)-1-[(1-methylethyl)amino]-3-(2-prop-2-en-1-ylphenoxy)propan-2-ol, Beta-2 adrenergic receptor, Lysozyme, ...
Authors:Brown, M.A, Wacker, D, Fenalti, G, Katritch, V, Abagyan, R, Cherezov, V, Stevens, R.C, GPCR Network (GPCR)
Deposit date:2010-07-14
Release date:2010-08-11
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (3.16 Å)
Cite:Conserved Binding Mode of Human beta(2) Adrenergic Receptor Inverse Agonists and Antagonist Revealed by X-ray Crystallography
J.Am.Chem.Soc., 132, 2010
3NY8
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BU of 3ny8 by Molmil
Crystal structure of the human beta2 adrenergic receptor in complex with the inverse agonist ICI 118,551
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S,3S)-1-[(7-methyl-2,3-dihydro-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]butan-2-ol, Beta-2 adrenergic receptor, ...
Authors:Wacker, D, Fenalti, G, Brown, M.A, Katritch, V, Abagyan, R, Cherezov, V, Stevens, R.C, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), GPCR Network (GPCR)
Deposit date:2010-07-14
Release date:2010-08-11
Last modified:2024-11-27
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Conserved Binding Mode of Human beta(2) Adrenergic Receptor Inverse Agonists and Antagonist Revealed by X-ray Crystallography
J.Am.Chem.Soc., 132, 2010
4IAR
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BU of 4iar by Molmil
Crystal structure of the chimeric protein of 5-HT1B-BRIL in complex with ergotamine (PSI Community Target)
Descriptor: (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Chimera protein of human 5-hydroxytryptamine receptor 1B and E. Coli soluble cytochrome b562, Ergotamine
Authors:Wang, C, Jiang, Y, Ma, J, Wu, H, Wacker, D, Katritch, V, Han, G.W, Liu, W, Huang, X, Vardy, E, McCorvy, J.D, Gao, X, Zhou, E.X, Melcher, K, Zhang, C, Bai, F, Yang, H, Yang, L, Jiang, H, Roth, B.L, Cherezov, V, Stevens, R.C, Xu, H.E, GPCR Network (GPCR)
Deposit date:2012-12-07
Release date:2013-03-13
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for molecular recognition at serotonin receptors.
Science, 340, 2013
8C9W
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BU of 8c9w by Molmil
Crystal structure of the adenosine A2A receptor (construct A2A-PSB2-bRIL) complexed with Etrumadenant at the orthosteric pocket
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3-[2-azanyl-6-[1-[[6-(2-oxidanylpropan-2-yl)pyridin-2-yl]methyl]-1,2,3-triazol-4-yl]pyrimidin-4-yl]-2-methyl-benzenecarbonitrile, ...
Authors:Strater, N, Claff, T, Schlegel, J.G, Voss, J.H, Vaassen, V, Muller, C.E.
Deposit date:2023-01-23
Release date:2023-07-12
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.114 Å)
Cite:Crystal structure of adenosine A 2A receptor in complex with clinical candidate Etrumadenant reveals unprecedented antagonist interaction.
Commun Chem, 6, 2023
6WGT
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BU of 6wgt by Molmil
Crystal structure of HTR2A with hallucinogenic agonist
Descriptor: (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide, 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562 fusion, CHOLESTEROL, ...
Authors:Kim, K.L, Che, T, Krumm, B.E, Roth, B.L.
Deposit date:2020-04-06
Release date:2020-09-23
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structure of a Hallucinogen-Activated Gq-Coupled 5-HT 2A Serotonin Receptor
Cell(Cambridge,Mass.), 182, 2020
6WQA
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2.0A angstrom A2a adenosine receptor structure using XFEL data collected in helium atmosphere.
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, ...
Authors:Lee, M.-Y, Geiger, J, Ishchenko, A, Han, G.W, Barty, A, White, T.A, Gati, C, Batyuk, A, Hunter, M.S, Aquila, A, Boutet, S, Weierstall, U, Cherezov, V, Liu, W.
Deposit date:2020-04-28
Release date:2020-11-18
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Harnessing the power of an X-ray laser for serial crystallography of membrane proteins crystallized in lipidic cubic phase
Iucrj, 7, 2020

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