7PIU
Cryo-EM structure of the agonist setmelanotide bound to the active melanocortin-4 receptor (MC4R) in complex with the heterotrimeric Gs protein at 2.6 A resolution.
Summary for 7PIU
Entry DOI | 10.2210/pdb7piu/pdb |
Related | 7PIV |
EMDB information | 13453 13454 |
Descriptor | Melanocortin receptor 4, Setmelanotide (other names RM-493; BIM-22493; IRC-022493; Imcivree), Isoform Gnas-2 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... (8 entities in total) |
Functional Keywords | gpcr, melanocortin-4 receptor, melanocortin receptors, setmelanotide, ndp-alpha-msh, alpha-msh, antagonism, agonism, appetite regulation, anti-obesity treatment, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 144449.67 |
Authors | Heyder, N.A.,Schmidt, A.,Kleinau, G.,Hilal, T.,Scheerer, P. (deposition date: 2021-08-23, release date: 2021-11-17) |
Primary citation | Heyder, N.A.,Kleinau, G.,Speck, D.,Schmidt, A.,Paisdzior, S.,Szczepek, M.,Bauer, B.,Koch, A.,Gallandi, M.,Kwiatkowski, D.,Burger, J.,Mielke, T.,Beck-Sickinger, A.G.,Hildebrand, P.W.,Spahn, C.M.T.,Hilger, D.,Schacherl, M.,Biebermann, H.,Hilal, T.,Kuhnen, P.,Kobilka, B.K.,Scheerer, P. Structures of active melanocortin-4 receptor-Gs-protein complexes with NDP-alpha-MSH and setmelanotide. Cell Res., 31:1176-1189, 2021 Cited by PubMed: 34561620DOI: 10.1038/s41422-021-00569-8 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.58 Å) |
Structure validation
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