8RLN

Crystal structure of human adenosine A2A receptor (construct A2A-PSB2-bRIL) complexed with the partial antagonist LUF5834 at the orthosteric pocket

This is a non-PDB format compatible entry.

Summary for 8RLN

• Entry DOI: 10.2210/pdb8rln/pdb
• Descriptor: Adenosine receptor A2a,Soluble cytochrome b562, CHOLESTEROL, OLEIC ACID, ... (8 entities in total)
• Functional Keywords: gpcr, bril, antagonist, purinergic signaling, cancer immunotherapy, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 1
• Total formula weight: 52327.53

Authors

Strater, N.,Claff, T.,Weisse, R.H.,Muller, C.E. (deposition date: 2024-01-03, release date: 2024-06-19)

• Primary citation: Claff, T.,Mahardhika, A.B.,Vaassen, V.J.,Schlegel, J.G.,Vielmuth, C.,Weisse, R.H.,Strater, N.,Muller, C.E.; Structural Insights into Partial Activation of the Prototypic G Protein-Coupled Adenosine A 2A Receptor.; Acs Pharmacol Transl Sci, 7:1415-1425, 2024; PubMed: 38751633; DOI: 10.1021/acsptsci.4c00051

Experimental method

X-RAY DIFFRACTION (2.43 Å)