5CXV
Structure of the human M1 muscarinic acetylcholine receptor bound to antagonist Tiotropium
Summary for 5CXV
Entry DOI | 10.2210/pdb5cxv/pdb |
Descriptor | Muscarinic acetylcholine receptor M1,Endolysin,Muscarinic acetylcholine receptor M1, FLAG peptide, (1R,2R,4S,5S,7S)-7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane, ... (8 entities in total) |
Functional Keywords | acetylcholine, allosteric regulation, carrier proteins, cholinergic antagonists, tiotropium receptor, muscarinic m1, gpcr, subtype selectivity, hydrolase |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane; Multi-pass membrane protein: P11229 |
Total number of polymer chains | 2 |
Total formula weight | 60846.89 |
Authors | Sun, B.,Feng, D.,Li, X.,Kobilka, T.S.,Kobilka, B.K. (deposition date: 2015-07-29, release date: 2016-03-09, Last modification date: 2016-03-30) |
Primary citation | Thal, D.M.,Sun, B.,Feng, D.,Nawaratne, V.,Leach, K.,Felder, C.C.,Bures, M.G.,Evans, D.A.,Weis, W.I.,Bachhawat, P.,Kobilka, T.S.,Sexton, P.M.,Kobilka, B.K.,Christopoulos, A. Crystal structures of the M1 and M4 muscarinic acetylcholine receptors. Nature, 531:335-340, 2016 Cited by PubMed: 26958838DOI: 10.1038/nature17188 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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