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5CXV

Structure of the human M1 muscarinic acetylcholine receptor bound to antagonist Tiotropium

Summary for 5CXV
Entry DOI10.2210/pdb5cxv/pdb
DescriptorMuscarinic acetylcholine receptor M1,Endolysin,Muscarinic acetylcholine receptor M1, FLAG peptide, (1R,2R,4S,5S,7S)-7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane, ... (8 entities in total)
Functional Keywordsacetylcholine, allosteric regulation, carrier proteins, cholinergic antagonists, tiotropium receptor, muscarinic m1, gpcr, subtype selectivity, hydrolase
Biological sourceHomo sapiens (Human)
More
Cellular locationCell membrane; Multi-pass membrane protein: P11229
Total number of polymer chains2
Total formula weight60846.89
Authors
Sun, B.,Feng, D.,Li, X.,Kobilka, T.S.,Kobilka, B.K. (deposition date: 2015-07-29, release date: 2016-03-09, Last modification date: 2016-03-30)
Primary citationThal, D.M.,Sun, B.,Feng, D.,Nawaratne, V.,Leach, K.,Felder, C.C.,Bures, M.G.,Evans, D.A.,Weis, W.I.,Bachhawat, P.,Kobilka, T.S.,Sexton, P.M.,Kobilka, B.K.,Christopoulos, A.
Crystal structures of the M1 and M4 muscarinic acetylcholine receptors.
Nature, 531:335-340, 2016
Cited by
PubMed: 26958838
DOI: 10.1038/nature17188
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.7 Å)
Structure validation

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