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5CXV

Structure of the human M1 muscarinic acetylcholine receptor bound to antagonist Tiotropium

Functional Information from GO Data
ChainGOidnamespacecontents
A0003796molecular_functionlysozyme activity
A0003824molecular_functioncatalytic activity
A0004930molecular_functionG protein-coupled receptor activity
A0005886cellular_componentplasma membrane
A0007186biological_processG protein-coupled receptor signaling pathway
A0009253biological_processpeptidoglycan catabolic process
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0016798molecular_functionhydrolase activity, acting on glycosyl bonds
A0016907molecular_functionG protein-coupled acetylcholine receptor activity
A0016998biological_processcell wall macromolecule catabolic process
A0030430cellular_componenthost cell cytoplasm
A0031640biological_processkilling of cells of another organism
A0040012biological_processregulation of locomotion
A0042742biological_processdefense response to bacterium
A0044659biological_processviral release from host cell by cytolysis
A0046541biological_processsaliva secretion
A0050890biological_processcognition
Functional Information from PDB Data
site_idAC1
Number of Residues15
Detailsbinding site for residue 0HK A 501
ChainResidue
AASP105
ATRP378
ATYR381
AASN382
ATYR404
ACYS407
ATYR408
ATYR106
ASER109
ATRP157
ATHR189
ATHR192
AALA193
AALA196
APHE197

site_idAC2
Number of Residues6
Detailsbinding site for residue Y01 A 502
ChainResidue
ATRP23
APHE50
ALYS57
ATYR62
ALEU65
ATRP150

site_idAC3
Number of Residues2
Detailsbinding site for residue EDO A 503
ChainResidue
AGLN165
AGLY169

site_idAC4
Number of Residues5
Detailsbinding site for residue PGE A 504
ChainResidue
AILE119
AARG123
AGLU360
CASP1
CTYR2

site_idAC5
Number of Residues2
Detailsbinding site for residue EDO A 505
ChainResidue
AGLU1010
AGOL506

site_idAC6
Number of Residues5
Detailsbinding site for residue GOL A 506
ChainResidue
AGLY1029
ALEU1031
AASP1069
APHE1103
AEDO505

site_idAC7
Number of Residues4
Detailsbinding site for residue EDO A 507
ChainResidue
ATHR1141
APRO1142
AASN1143
AARG1144

Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASVmNLLLISFDRYFsV
ChainResidueDetails
AALA111-VAL127

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsActive site: {"description":"Proton donor/acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_04110","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"3382407","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7831309","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8266098","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues1
DetailsActive site: {"description":"Proton donor/acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_04110","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1892846","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3382407","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7831309","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8266098","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"8266098","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"7831309","evidenceCode":"ECO:0000303"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues25
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"32646996","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WJC","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues33
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"32646996","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WJC","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues21
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"32646996","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WJC","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues36
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"32646996","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WJC","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues25
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"32646996","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WJC","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues21
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"32646996","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WJC","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues23
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"32646996","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WJC","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues23
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"32646996","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WJC","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI13
Number of Residues22
DetailsTransmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"32646996","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WJC","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI14
Number of Residues9
DetailsCompositional bias: {"description":"Low complexity","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails

site_idSWS_FT_FI15
Number of Residues4
DetailsSite: {"description":"Subtype-specific residue that binds to snake venom muscarinic toxin 7","evidences":[{"source":"PubMed","id":"32646996","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI16
Number of Residues1
DetailsSite: {"description":"Binds to snake venom muscarinic toxin 7","evidences":[{"source":"PubMed","id":"32646996","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI17
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P12657","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI18
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

Catalytic Information from CSA
site_idMCSA1
Number of Residues2
DetailsM-CSA 921
ChainResidueDetails
AGLU1010proton shuttle (general acid/base)
AASP1019covalent catalysis

239492

PDB entries from 2025-07-30

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