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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

5CXV

Structure of the human M1 muscarinic acetylcholine receptor bound to antagonist Tiotropium

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		Muscarinic acetylcholine receptor M1,Endolysin,Muscarinic acetylcholine receptor M1polymer51558653.41UniProt (P11229)
UniProt (P00720)
Pfam (PF00001)
Pfam (PF00959)		Homo sapiens (Human)Lysis protein,Lysozyme,Muramidase
2B
(C)		FLAG peptidepolymer7885.81Enterobacteria phage T4
3C
(A)		(1R,2R,4S,5S,7S)-7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonanenon-polymer392.51Chemie (0HK)
PubChem (656611)
PubChem (3086655)
PubChem (5487427)
PubChem (5748851)
PubChem (9804844)
PubChem (11598033)
PubChem (15057856)
PubChem (50909376)
PubChem (60831)
PubChem (131951)
PubChem (123134303)
PubChem (58667495)
PubChem (59084585)
PubChem (59168855)
PubChem (59288009)
PubChem (60003260)
PubChem (87909275)
PubChem (98047845)
PubChem (122130800)
PubChem (124527228)
4D
(A)		CHOLESTEROL HEMISUCCINATEnon-polymer486.71Chemie (Y01)
PubChem (65082)
PubChem (363416)
PubChem (500055)
PubChem (13301926)
PubChem (13301927)
PubChem (16219150)
PubChem (22210610)
PubChem (45489984)
PubChem (57163942)
PubChem (89891013)
PubChem (99567468)
PubChem (124427194)
PubChem (124897021)
PubChem (124897020)
PubChem (10005657)
PubChem (130340716)
PubChem (11969853)
PubChem (137392566)
PubChem (137496323)
PubChem (155804219)
PubChem (169132514)
PubChem (60078761)
PubChem (73440805)
PubChem (99567469)
PubChem (124301053)
PubChem (124302591)
PubChem (124303794)
PubChem (124421343)
PubChem (124427195)
PubChem (124914595)
PubChem (124914596)
PubChem (131705526)
PubChem (137332121)
PubChem (137496357)
PubChem (146157332)
PubChem (154929912)
PubChem (155199678)
PubChem (156327905)
PubChem (156426247)
PubChem (156516588)
PubChem (166979870)
PubChem (167024614)
PubChem (169132513)
PubChem (170117245)
PubChem (172400028)
5E, G, I
(A)		1,2-ETHANEDIOLnon-polymer62.13Chemie (EDO)
6F
(A)		TRIETHYLENE GLYCOLnon-polymer150.21Chemie (PGE)
7H
(A)		GLYCEROLnon-polymer92.11Chemie (GOL)
PubChem (753)
8J, K
(A, C)		waterwater18.010Chemie (HOH)
Sequence modifications
A: 2 - 218 (UniProt: P11229)
PDBExternal DatabaseDetails
Met -24-initiating methionine
Lys -23-expression tag
Thr -22-expression tag
Ile -21-expression tag
Ile -20-expression tag
Ala -19-expression tag
Leu -18-expression tag
Ser -17-expression tag
Tyr -16-expression tag
Ile -15-expression tag
Phe -14-expression tag
Cys -13-expression tag
Leu -12-expression tag
Val -11-expression tag
Phe -10-expression tag
Ala -9-expression tag
Asp -8-expression tag
Tyr -7-expression tag
Lys -6-expression tag
Asp -5-expression tag
Asp -4-expression tag
Asp -3-expression tag
Asp -2-expression tag
Ala -1-expression tag
Ala 0-expression tag
Ala 1-expression tag
Gln 2Asn 2engineered mutation
Gln 12Asn 12engineered mutation
Gln 110Asn 110engineered mutation
A: 1001 - 1160 (UniProt: P00720)
PDBExternal DatabaseDetails
Gly 1011Arg 12variant
Thr 1053Cys 54engineered mutation
Ala 1096Cys 97engineered mutation
Arg 1136Ile 137variant
A: 355 - 460 (UniProt: P11229)
PDBExternal DatabaseDetails
His 461-expression tag
His 462-expression tag
His 463-expression tag
His 464-expression tag
His 465-expression tag
His 466-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight59539.2
Non-Polymers*Number of molecules7
Total formula weight1307.7
All*Total formula weight60846.9
*Water molecules are not included.

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PDB entries from 2026-04-08

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