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5XR8

Crystal structure of the human CB1 in complex with agonist AM841

Summary for 5XR8
Entry DOI10.2210/pdb5xr8/pdb
DescriptorCannabinoid receptor 1,Flavodoxin,Cannabinoid receptor 1, FLAVIN MONONUCLEOTIDE, (6~{a}~{R},9~{R},10~{a}~{R})-9-(hydroxymethyl)-3-(8-isothiocyanato-2-methyl-octan-2-yl)-6,6-dimethyl-6~{a},7,8,9,10,10~{a}-hexahydrobenzo[c]chromen-1-ol, ... (6 entities in total)
Functional Keywordsmembrane protein, human g protein-coupled receptor, stabilizing agonists, lipidic cubic phase, signaling protein
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains1
Total formula weight50022.36
Authors
Primary citationHua, T.,Vemuri, K.,Nikas, S.P.,Laprairie, R.B.,Wu, Y.,Qu, L.,Pu, M.,Korde, A.,Jiang, S.,Ho, J.H.,Han, G.W.,Ding, K.,Li, X.,Liu, H.,Hanson, M.A.,Zhao, S.,Bohn, L.M.,Makriyannis, A.,Stevens, R.C.,Liu, Z.J.
Crystal structures of agonist-bound human cannabinoid receptor CB1.
Nature, 547:468-471, 2017
Cited by
PubMed: 28678776
DOI: 10.1038/nature23272
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.95 Å)
Structure validation

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