5XR8
Crystal structure of the human CB1 in complex with agonist AM841
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cannabinoid receptor 1,Flavodoxin,Cannabinoid receptor 1 | polymer | 438 | 48627.6 | 1 | UniProt (P21554) UniProt (P00323) Pfam (PF00001) Pfam (PF00258) | Homo sapiens (Human) | CB1,CANN6,CB1,CANN6 |
| 2 | B (A) | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 1 | Chemie (FMN) | |||
| 3 | C (A) | (6~{a}~{R},9~{R},10~{a}~{R})-9-(hydroxymethyl)-3-(8-isothiocyanato-2-methyl-octan-2-yl)-6,6-dimethyl-6~{a},7,8,9,10,10~{a}-hexahydrobenzo[c]chromen-1-ol | non-polymer | 445.7 | 1 | Chemie (8D0) | |||
| 4 | D (A) | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) | |||
| 5 | E (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 6 | F (A) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A: 99 - 306 (UniProt: P21554)
A: 308 - 453 (UniProt: P00323)
A: null - 536 (UniProt: P21554)
| PDB | External Database | Details |
|---|---|---|
| Ala 210 | Thr 210 | engineered mutation |
| Lys 273 | Glu 273 | engineered mutation |
| Val 283 | Thr 283 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Trp 403 | Tyr 98 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ala 307 | - | linker |
| Glu 462 | Arg 340 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 48627.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1394.8 | |
| All* | Total formula weight | 50022.4 |
