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7DOK
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BU of 7dok by Molmil
Structure of COVID-19 RNA-dependent RNA polymerase (extended conformation) bound to penciclovir
Descriptor: MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ...
Authors:Li, Z, Yu, X.
Deposit date:2020-12-14
Release date:2021-12-15
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (2.73 Å)
Cite:Structural basis for repurpose and design of nucleotide drugs for treating COVID-19
To Be Published
7DOI
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BU of 7doi by Molmil
Structure of COVID-19 RNA-dependent RNA polymerase bound to penciclovir.
Descriptor: MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ...
Authors:Li, Z, Yu, X.
Deposit date:2020-12-14
Release date:2021-12-15
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Structural basis for repurpose and design of nucleotide drugs for treating COVID-19
To Be Published
7DFH
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BU of 7dfh by Molmil
Structure of COVID-19 RNA-dependent RNA polymerase bound to ribavirin
Descriptor: MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ...
Authors:Li, Z, Zhou, Z, Yu, X.
Deposit date:2020-11-08
Release date:2021-11-17
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (2.97 Å)
Cite:Structural basis for repurpose and design of nucleotide drugs for treating COVID-19
To Be Published
7DFG
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BU of 7dfg by Molmil
Structure of COVID-19 RNA-dependent RNA polymerase bound to favipiravir
Descriptor: 6-fluoro-3-oxo-4-(5-O-phosphono-beta-D-ribofuranosyl)-3,4-dihydropyrazine-2-carboxamide, MAGNESIUM ION, Non-structural protein 7, ...
Authors:Li, Z, Zhou, Z, Yu, X.
Deposit date:2020-11-08
Release date:2021-11-17
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structural basis for repurpose and design of nucleotide drugs for treating COVID-19
To Be Published
7D4F
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BU of 7d4f by Molmil
Structure of COVID-19 RNA-dependent RNA polymerase bound to suramin
Descriptor: 8-(3-(3-aminobenzamido)-4-methylbenzamido)naphthalene-1,3,5-trisulfonic acid, Non-structural protein 7, Non-structural protein 8, ...
Authors:Li, Z, Yin, W, Zhou, Z, Yu, X, Xu, H.
Deposit date:2020-09-23
Release date:2020-11-11
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (2.57 Å)
Cite:Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin.
Nat.Struct.Mol.Biol., 28, 2021
7CYQ
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BU of 7cyq by Molmil
Cryo-EM structure of an extended SARS-CoV-2 replication and transcription complex reveals an intermediate state in cap synthesis
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Helicase, MAGNESIUM ION, ...
Authors:Yan, L, Ge, J, Zheng, L, Zhang, Y, Gao, Y, Wang, T, Wang, H, Huang, Y, Li, M, Wang, Q, Rao, Z, Lou, Z.
Deposit date:2020-09-04
Release date:2020-12-09
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (2.83 Å)
Cite:Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis.
Cell, 184, 2021
7CXN
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BU of 7cxn by Molmil
Architecture of a SARS-CoV-2 mini replication and transcription complex
Descriptor: Helicase, Non-structural protein 7, Non-structural protein 8, ...
Authors:Yan, L, Zhang, Y, Ge, J, Zheng, L, Gao, Y, Wang, T, Jia, Z, Wang, H, Huang, Y, Li, M, Wang, Q, Rao, Z, Lou, Z.
Deposit date:2020-09-02
Release date:2020-11-04
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.84 Å)
Cite:Architecture of a SARS-CoV-2 mini replication and transcription complex.
Nat Commun, 11, 2020
7CXM
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BU of 7cxm by Molmil
Architecture of a SARS-CoV-2 mini replication and transcription complex
Descriptor: Helicase, Non-structural protein 7, Non-structural protein 8, ...
Authors:Yan, L, Zhang, Y, Ge, J, Zheng, L, Gao, Y, Wang, T, Jia, Z, Wang, H, Huang, Y, Li, M, Wang, Q, Rao, Z, Lou, Z.
Deposit date:2020-09-02
Release date:2020-11-04
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Architecture of a SARS-CoV-2 mini replication and transcription complex.
Nat Commun, 11, 2020
7CTT
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BU of 7ctt by Molmil
Cryo-EM structure of Favipiravir bound to replicating polymerase complex of SARS-CoV-2 in the pre-catalytic state.
Descriptor: MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ...
Authors:Peng, Q, Peng, R, Shi, Y.
Deposit date:2020-08-20
Release date:2020-09-02
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural Basis of SARS-CoV-2 Polymerase Inhibition by Favipiravir.
Innovation (N Y), 2, 2021
7C2K
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BU of 7c2k by Molmil
COVID-19 RNA-dependent RNA polymerase pre-translocated catalytic complex
Descriptor: Non-structural protein 7, Non-structural protein 8, RNA (29-MER), ...
Authors:Wang, Q, Gao, Y, Ji, W, Mu, A, Rao, Z.
Deposit date:2020-05-07
Release date:2020-06-03
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (2.93 Å)
Cite:Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase.
Cell, 182, 2020
7BZF
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BU of 7bzf by Molmil
COVID-19 RNA-dependent RNA polymerase post-translocated catalytic complex
Descriptor: Non-structural protein 7, Non-structural protein 8, RNA (31-MER), ...
Authors:Wang, Q, Gao, Y, Ji, W, Mu, A, Rao, Z.
Deposit date:2020-04-27
Release date:2020-06-03
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.26 Å)
Cite:Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase.
Cell, 182, 2020
7BW4
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BU of 7bw4 by Molmil
Structure of the RNA-dependent RNA polymerase from SARS-CoV-2
Descriptor: Non-structural protein 7, Non-structural protein 8, RNA-directed RNA polymerase, ...
Authors:Peng, Q, Peng, R, Shi, Y.
Deposit date:2020-04-13
Release date:2020-05-27
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural and Biochemical Characterization of the nsp12-nsp7-nsp8 Core Polymerase Complex from SARS-CoV-2.
Cell Rep, 31, 2020
7BV2
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BU of 7bv2 by Molmil
The nsp12-nsp7-nsp8 complex bound to the template-primer RNA and triphosphate form of Remdesivir(RTP)
Descriptor: MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ...
Authors:Yin, W, Mao, C, Luan, X, Shen, D, Shen, Q, Su, H, Wang, X, Zhou, F, Zhao, W, Gao, M, Chang, S, Xie, Y.C, Tian, G, Jiang, H.W, Tao, S.C, Shen, J, Jiang, Y, Jiang, H, Xu, Y, Zhang, S, Zhang, Y, Xu, H.E.
Deposit date:2020-04-09
Release date:2020-04-22
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir.
Science, 368, 2020
7BV1
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BU of 7bv1 by Molmil
Cryo-EM structure of the apo nsp12-nsp7-nsp8 complex
Descriptor: Non-structural protein 7, Non-structural protein 8, RNA-directed RNA polymerase, ...
Authors:Yin, W, Mao, C, Luan, X, Shen, D, Shen, Q, Su, H, Wang, X, Zhou, F, Zhao, W, Gao, M, Chang, S, Xie, Y.C, Tian, G, Jiang, H.W, Tao, S.C, Shen, J, Jiang, Y, Jiang, H, Xu, Y, Zhang, S, Zhang, Y, Xu, H.E.
Deposit date:2020-04-09
Release date:2020-04-22
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir.
Science, 368, 2020
7BTF
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BU of 7btf by Molmil
SARS-CoV-2 RNA-dependent RNA polymerase in complex with cofactors in reduced condition
Descriptor: Non-structural protein 7, Non-structural protein 8, RNA-directed RNA polymerase, ...
Authors:Gao, Y, Yan, L, Huang, Y, Liu, F, Cao, L, Wang, T, Wang, Q, Lou, Z, Rao, Z.
Deposit date:2020-04-01
Release date:2020-04-08
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (2.95 Å)
Cite:Structure of the RNA-dependent RNA polymerase from COVID-19 virus.
Science, 368, 2020
7B3D
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BU of 7b3d by Molmil
Structure of elongating SARS-CoV-2 RNA-dependent RNA polymerase with AMP at position -4 (structure 3)
Descriptor: RNA (5'-R(P*CP*UP*AP*CP*GP*CP*AP*GP*UP*G)-3'), RNA (5'-R(P*UP*GP*CP*AP*CP*UP*GP*CP*GP*UP*AP*G)-3'), SARS-CoV-2 RNA-dependent RNA polymerase nsp12, ...
Authors:Kokic, G, Hillen, H.S, Tegunov, D, Dienemann, C, Seitz, F, Schmitzova, J, Farnung, L, Siewert, A, Hoebartner, C, Cramer, P.
Deposit date:2020-11-30
Release date:2020-12-23
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Mechanism of SARS-CoV-2 polymerase stalling by remdesivir.
Nat Commun, 12, 2021
7B3C
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BU of 7b3c by Molmil
Structure of elongating SARS-CoV-2 RNA-dependent RNA polymerase with Remdesivir at position -4 (structure 2)
Descriptor: DNA/RNA (5'-R(P*CP*UP*AP*CP*GP*CP*A)-D(P*(RMP))-R(P*GP*UP*G)-3'), Non-structural protein 7, Non-structural protein 8, ...
Authors:Kokic, G, Hillen, H.S, Tegunov, D, Dienemann, C, Seitz, F, Schmitzova, J, Farnung, L, Siewert, A, Hoebartner, C, Cramer, P.
Deposit date:2020-11-30
Release date:2020-12-23
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Mechanism of SARS-CoV-2 polymerase stalling by remdesivir.
Nat Commun, 12, 2021
7B3B
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BU of 7b3b by Molmil
Structure of elongating SARS-CoV-2 RNA-dependent RNA polymerase with Remdesivir at position -3 (structure 1)
Descriptor: DNA/RNA (5'-R(P*CP*UP*AP*CP*GP*CP*G)-D(P*(RMP))-R(P*UP*G)-3'), Non-structural protein 7, Non-structural protein 8, ...
Authors:Kokic, G, Hillen, H.S, Tegunov, D, Dienemann, C, Seitz, F, Schmitzova, J, Farnung, L, Siewert, A, Hoebartner, C, Cramer, P.
Deposit date:2020-11-30
Release date:2020-12-23
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Mechanism of SARS-CoV-2 polymerase stalling by remdesivir.
Nat Commun, 12, 2021
7AAP
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BU of 7aap by Molmil
Nsp7-Nsp8-Nsp12 SARS-CoV2 RNA-dependent RNA polymerase in complex with template:primer dsRNA and favipiravir-RTP
Descriptor: MAGNESIUM ION, Non-structural protein 12, Non-structural protein 7, ...
Authors:Naydenova, K, Muir, K.W, Wu, L.F, Zhang, Z, Coscia, F, Peet, M, Castro-Hartman, P, Qian, P, Sader, K, Dent, K, Kimanius, D, Sutherland, J.D, Lowe, J, Barford, D, Russo, C.J.
Deposit date:2020-09-04
Release date:2020-09-23
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Structure of the SARS-CoV-2 RNA-dependent RNA polymerase in the presence of favipiravir-RTP.
Proc.Natl.Acad.Sci.USA, 118, 2021
6YYT
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BU of 6yyt by Molmil
Structure of replicating SARS-CoV-2 polymerase
Descriptor: RNA product, ZINC ION, nsp12, ...
Authors:Hillen, H.S, Kokic, G, Farnung, L, Dienemann, C, Tegunov, D, Cramer, P.
Deposit date:2020-05-06
Release date:2020-05-13
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structure of replicating SARS-CoV-2 polymerase.
Nature, 584, 2020
6XQB
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BU of 6xqb by Molmil
SARS-CoV-2 RdRp/RNA complex
Descriptor: MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ...
Authors:Liu, B, Shi, W, Yang, Y.
Deposit date:2020-07-09
Release date:2020-07-29
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structure of SARS-CoV-2 RdRp/RNA complex at 3.4 Angstroms resolution
To Be Published
6XEZ
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BU of 6xez by Molmil
Structure of SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, CHAPSO, ...
Authors:Chen, J, Malone, B, Llewellyn, E.C, Campbell, E.A, Darst, S.A.
Deposit date:2020-06-14
Release date:2020-07-29
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex.
Cell, 182, 2020
6S2L
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BU of 6s2l by Molmil
FMDV 3D polymerase crystallized in presence of (F)uridylylated VPg peptide
Descriptor: GLYCEROL, Genome polyprotein
Authors:Verdaguer, N, Ferrer-Orta, C.
Deposit date:2019-06-21
Release date:2019-07-03
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:(F)uridylylated Peptides Linked to VPg1 of Foot-and- Mouth Disease Virus (FMDV): Design, Synthesis and X-Ray Crystallography of the Complexes with FMDV RNA-Dependent RNA Polymerase.
Molecules, 24, 2019
6R1I
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BU of 6r1i by Molmil
Structure of porcine Aichi virus polymerase
Descriptor: Genome polyprotein
Authors:Dubankova, A, Boura, E.
Deposit date:2019-03-14
Release date:2019-10-09
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.634 Å)
Cite:Structures of kobuviral and siciniviral polymerases reveal conserved mechanism of picornaviral polymerase activation.
J.Struct.Biol., 208, 2019
6QWT
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BU of 6qwt by Molmil
Sicinivirus 3Dpol RNA dependent RNA polymerase
Descriptor: Genome polyprotein
Authors:Dubankova, A, Boura, E.
Deposit date:2019-03-06
Release date:2019-10-09
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of kobuviral and siciniviral polymerases reveal conserved mechanism of picornaviral polymerase activation.
J.Struct.Biol., 208, 2019

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PDB entries from 2024-09-18

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